Stem Cell-Based Strategies for Skin Regeneration and Repair: Current Approaches, Preclinical, and Clinical Evidence

    July 2026 in “ Current Stem Cell Reports ”
    Keerthiraj Kalmantidoddi Shivaji, Balamuralidhara Veeranna, Soundarya Raju … Sagar Guruswamy
    Studysummary This review highlights that stem cell-based therapies show promise in skin regeneration for conditions like chronic wounds and burns due to their regenerative and immunomodulatory effects, though challenges like safety and scalability limit widespread clinical use.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 21

    1. Bioengineering Strategies for Regeneration of Skin Integrity: A Literature Review Regenerative Therapy · 2024
    2. In Vitro Differentiation of Hair-Follicle Bulge Stem Cells Into Synaptophysin-Expressing Neurons: A Potential New Approach for Neuro-Regeneration Human Cell · 2024
    3. Organoids in Skin Wound Healing Burns & Trauma · 2024
    4. Stem Cell Activity-Coupled Suppression of Endogenous Retrovirus Governs Adult Tissue Regeneration Cell · 2024
    5. Epidermal Stem Cells: Skin Surveillance And Clinical Perspective Journal of Translational Medicine · 2024
    6. Stem-Cell Therapy in Dermatology: Challenges and Opportunities Indian Journal of Skin Allergy · 2024
    7. Role of Umbilical Cord Mesenchymal Stromal Cells in Skin Rejuvenation npj Regenerative Medicine · 2024
    8. Skin Pigmentation Types, Causes and Treatment: A Review Molecules · 2023
    9. Application of Stem Cells in Regenerative Medicine MedComm · 2023
    10. Stem Cell Applications in Human Hair Growth: A Literature Review Cureus · 2023
    11. Single-Stage Transplantation with Epidermal Stem Cells Enhances Survival of Tissue-Engineered Skin by Inducing Early Angiogenesis Stem Cell Research & Therapy · 2023
    12. Alpinetin Promotes Hair Regeneration via Activating Hair Follicle Stem Cells Chinese medicine · 2022
    13. Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle Stem Cell Research & Therapy · 2021
    14. Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway Frontiers in Bioengineering and Biotechnology · 2021
    15. Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation International Journal of Molecular Sciences · 2021
    16. Combination of Lyophilized Adipose-Derived Stem Cell Concentrated Conditioned Medium and Polysaccharide Hydrogel in the Inhibition of Hypertrophic Scarring Stem Cell Research & Therapy · 2021
    17. The Dynamics of the Skin’s Immune System International Journal of Molecular Sciences · 2019
    18. Tissue Engineering of Skin and Regenerative Medicine for Wound Care Burns & Trauma · 2018
    19. Advances in Hair Restoration Dermatologic Clinics · 2017
    20. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    21. A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice Stem Cells International · 2017