Immunohistochemical Expression of Sox9 and CD34 in Androgenetic Alopecia Patients

    Heba A.S. Bazid, Alaa H. Marae, Hadeer E. Gaber, Rania Abdallah Abdallah
    TLDR CD34+ cells decrease in bald areas, while Sox9 stays high, suggesting hair loss in AGA is linked to stem cell issues.
    This study investigated the immunohistochemical expression of Sox9 and CD34 in androgenetic alopecia (AGA) patients, involving 40 subjects: 14 males with AGA, 6 females with female pattern hair loss, and 20 healthy controls. Scalp biopsies revealed that CD34 expression was present in all control samples but only in 60% of frontal bald samples from AGA patients, indicating a decline in CD34+ progenitor cells in affected areas. Conversely, Sox9 expression remained high across all samples, suggesting that the dysregulated conversion of hair follicle stem cells (HFSCs) to progenitor cells may significantly contribute to AGA pathogenesis.
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