A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features

    March 2016 in “ Nature Communications ”
    Kaustubh Adhikari, Tania Fontanil, Santiago Cal … Andrés Ruiz‐Linares
    Studysummary In this study, researchers identified 18 genetic associations with scalp and facial hair traits in Latin Americans, including novel loci for hair greying and balding, with implications for understanding hair evolution.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on nature.com →
    Discuss this study in the Community →

    Research cited in this study 19

    1. Hair Coloration by Gene Regulation: Fact or Fiction? Trends in biotechnology · 2015
    2. Evaluation of the Predictive Capacity of DNA Variants Associated with Straight Hair in Europeans Forensic Science International: Genetics · 2015
    3. Admixture in Latin America: Geographic Structure, Phenotypic Diversity, and Self-Perception of Ancestry Based on 7,342 Individuals PLOS Genetics · 2014
    4. Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages Journal of Investigative Dermatology · 2014
    5. Regionalization of the Skin Seminars in cell & developmental biology · 2013
    6. Protease Activity, Localization, and Inhibition in the Human Hair Follicle International Journal of Cosmetic Science · 2013
    7. The Biology of Hair Diversity International Journal of Cosmetic Science · 2013
    8. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    9. Sostdc1 Defines the Size and Number of Skin Appendage Placodes Developmental biology · 2012
    10. The Mouse Frizzy (Fr) And Rat ‘Hairless’ (FrCR) Mutations Are Natural Variants Of Protease Serine S1 Family Member 8 (Prss8) Experimental Dermatology · 2010
    11. Why Some Women Look Young for Their Age PLOS ONE · 2009
    12. Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans American journal of human genetics · 2009
    13. A Replication Study Confirmed the EDAR Gene to Be a Major Contributor to Population Differentiation Regarding Head Hair Thickness in Asia Human genetics · 2008
    14. Enhanced Ectodysplasin-A Receptor Signaling Alters Multiple Fiber Characteristics to Produce the East Asian Hair Form Human mutation · 2008
    15. Human Tissue Kallikreins as Promiscuous Modulators of Homeostatic Skin Barrier Functions Biological Chemistry · 2008
    16. Worldwide Diversity of Hair Curliness: A New Method of Assessment International Journal of Dermatology · 2007
    17. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    18. Trichohyalin Mechanically Strengthens the Hair Follicle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    19. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002

    Related research 6

    1. Variation of Hair Follicle Counts Among Different Scalp Areas: A Quantitative Histopathological Study Skin Appendage Disorders · 2021
    2. Characteristics of Nonbalding Scalp Zones of Androgenetic Alopecia in East Asians Clinical and Experimental Dermatology · 2014
    3. Hair Counts from Normal Scalp Biopsy in Taiwan Dermatologic Surgery · 2012
    4. Intermediate Hair Follicles: A New, More Clinically Relevant Model for Hair Growth Investigations British Journal of Dermatology · 2010
    5. Surgical Treatment of Secondary Cicatricial Alopecia of Scalp and Eyebrow Indian Journal of Plastic Surgery · 2009
    6. Original Study: Morphometric Analysis of Alopecia Areata and Androgenetic Alopecia in Koreans 대한피부과학회지 · 2001