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research Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene

January 2022 in “Mammalian Genome”

This study found that the wavy coat trait in Nakano cataract mice is polygenic, involving major and minor genes, and resembles human curly scalp hair associated with the PRSS53 gene alteration.

research A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

196 citations , March 2016 in “Nature Communications”

In this study, researchers identified 18 genetic associations with scalp and facial hair traits in Latin Americans, including novel loci for hair greying and balding, with implications for understanding hair evolution.

research Fibrotic enzymes modulate wound‐induced skin tumorigenesis

15 citations , March 2021 in “EMBO Reports”

PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.

research A direct link betweenPrss53, hair curvature, and skeletal dysplasia

February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that Prss53-mutated rabbits exhibited curved hair and skeletal dyskinesia, suggesting a link between Prss53 loss and these traits, potentially involving disrupted calcium metabolism.

research The biology and genetics of curly hair

65 citations , March 2017 in “Experimental Dermatology”

This review discusses the genetic and biological factors influencing hair curliness, revealing strong links to specific protein variations, and reports no new clinical results.

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi