ROS-Responsive Hydrogel-Delivered miR-665 Targets STAT3 to Alleviate Inflammation and Promote Hair Follicle Regeneration in Alopecia Areata

    February 2026 in “ Journal of Nanobiotechnology ”
    Luo Wt, Wenjing TanTai, Qixiang Gui … Minjuan Wu
    Studysummary This study reports that a new ROS-responsive hydrogel platform delivering miR-665 effectively reduced inflammation and promoted hair follicle regeneration in AA, suggesting a promising treatment approach.
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    Research cited in this study 12

    1. Deciphering the Complex Immunopathogenesis of Alopecia Areata International Journal of Molecular Sciences · 2024
    2. Microneedle-Mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune-Mediated Alopecia Advanced Materials · 2024
    3. Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions Frontiers in immunology · 2023
    4. Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in Alopecia Areata Cell Biology International · 2023
    5. Alopecia Areata: What's New in the Epidemiology, Comorbidities, and Pathogenesis? Journal of Dermatological Science · 2023
    6. The Crosstalk Between PTEN-Induced Kinase 1-Mediated Mitophagy and the Inflammasome in the Pathogenesis of Alopecia Areata Experimental Dermatology · 2023
    7. Oxidative Stress and Antioxidant Markers in Patients with Alopecia Areata: A Comparative Cross-Sectional Study Indian journal of dermatology, venereology, and leprology · 2022
    8. Reversal of Alopecia Areata and Osteoporosis Following Treatment with Activation of TGR5 in Mice Bioscience Reports · 2021
    9. Alopecia Areata: An Autoimmune Disease of Multiple Players ImmunoTargets and therapy · 2021
    10. Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles International journal of molecular sciences · 2021
    11. Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata JCI insight · 2021
    12. JAK Inhibitors and Alopecia Areata Lancet · 2019