Exosomes Derived from Platelet-Rich Plasma Promote Hair Regeneration by Regulating the SIRT1/FoxO3a Pathway to Alleviate Oxidative Stress

    August 2025 in “ Regenerative Therapy ”
    Xin Yang, Ke Wang, Gao Liu … Chan Zhang
    Studysummary In this study, researchers observed that platelet-rich plasma-derived exosomes significantly promoted hair regeneration in a murine model of alopecia by enhancing hair follicle stem cell activities and modulating the SIRT1/FoxO3a pathway, suggesting potential clinical benefits for alopecia treatment.
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    Research cited in this study 19

    1. The Roles of Exosomes in Regulating Hair Follicle Growth Clinical Cosmetic and Investigational Dermatology · 2024
    2. Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
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