Exosomes Derived from Platelet-Rich Plasma Promote Hair Regeneration by Regulating the SIRT1/FoxO3a Pathway to Alleviate Oxidative Stress

The study demonstrates that exosomes derived from platelet-rich plasma (PRP-exos) can promote hair regeneration by alleviating oxidative stress through the SIRT1/FoxO3a pathway. PRP-exos enhance the proliferation and migration of hair follicle stem cells (HFSCs), reduce cell death, and protect against oxidative stress-induced damage. In vitro, they improve cell viability and mitigate apoptosis, while in vivo, they significantly increase hair growth in a mouse model by promoting hair follicles in the anagen phase. The upregulation of SIRT1 and subsequent deacetylation of FoxO3a lead to increased antioxidant enzyme expression, suggesting PRP-exos as a promising therapeutic strategy for alopecia.