Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Re-Growth in Androgenetic Alopecia. Biomolecular Pathway Analysis and Clinical Evaluation

    April 2019 in “Biomedicines
    Pietro Gentile, Maria Giovanna Scioli, Alessandra Bielli, Barbara De Angelis, Ciro De Sio, Domenico De Fazio, Gabriele Ceccarelli, Angelo Trivisonno, Augusto Orlandi, Valerio Cervelli, Simone Garcovich
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    TLDR PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.
    The study evaluated the effectiveness of platelet-rich plasma (PRP) and micrografts containing human follicle mesenchymal stem cells (HF-MSCs) as a potential treatment for androgenetic alopecia (AGA). The results showed significant increases in hair thickness, hair count, and hair density. The study found that PRP and/or HF-MSCs represent a promising therapy for AGA, and the increment of Wnt signaling in DPCs is the important factor that enhances hair re-growth. The treatment activated several pathways involved in hair growth and led to an increase in hair density and thickness, as well as an improvement in hair growth rate. The study suggests that this treatment can be an effective option for those with androgenetic alopecia.
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