Ovine Hair Follicle Stem Cells Derived from Single Vibrissae Reconstitute Haired Skin

August 2015 in “ International Journal of Molecular Sciences ”

Huishan Zhang, Shoubing Zhang, Huashan Zhao, Jingqiao Qiao, Shuang Liu, Zhili Deng, Xiaohua Lei, Lina Ning, Yujing Cao, Yong Zhao, Enkui Duan

TLDR Ovine hair follicle stem cells can regenerate haired skin and may improve wool production.

The study developed an efficient in vitro system to isolate and enrich ovine hair follicle stem cells (HFSCs) from the bulge area of vibrissa hair follicles. These bulge-derived keratinocytes, which were highly positive for markers such as Krt15, Krt14, Tp63, Krt19, and Itga6, demonstrated strong proliferation abilities and were capable of forming new epidermis, hair follicles, and sebaceous glands in skin reconstitution experiments. This method provided a significant advancement in obtaining multipotent ovine HFSCs, which could be used to investigate the ovine hair cycle and potentially enhance wool production.

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