Nitric Oxide-Releasing Nanocarriers Integrated with Ginsenoside Compound K in Dissolvable Microneedles for Androgenetic Alopecia

December 2025 in “ Journal of Nanobiotechnology ”

Guanghui Sun, Jianlin Liu, Guorui Jin, Jing Zhao, Xiaoyang Li, Xueqing Yu, Yu Mi

androgenetic alopecia microneedle-based drug delivery Ginsenoside Compound K S-nitrosoglutathione nitric oxide PI3K-AKT signaling pathway β-catenin reactive oxygen species angiogenesis hair follicle microenvironment AGA microneedles CK GSNO NO ROS

Studysummary This study introduced a novel microneedle-based system for androgenetic alopecia treatment, which delivered Ginsenoside Compound K and S-nitrosoglutathione to enhance hair regeneration by improving the hair follicle microenvironment and promoting follicular cell proliferation. Our plain-language summary of this paper — not a Tressless recommendation.

This study presents a novel microneedle-based drug delivery system (CK/GSNO@Lip MN) for treating androgenetic alopecia (AGA), a common hair loss disorder. The system co-delivers Ginsenoside Compound K (CK) and S-nitrosoglutathione (GSNO) to target the hair follicle microenvironment. CK activates the PI3K-AKT signaling pathway, upregulates β-catenin expression, modulates reactive oxygen species (ROS), and reduces inflammation. GSNO releases nitric oxide (NO) to enhance angiogenesis and regulate inflammation. Together, they promote hair regeneration by improving the follicle environment and cell proliferation, offering a promising approach for AGA and potential broader dermatological applications.

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