Evaluation of NF-κB as a Novel Serum Biomarker in Androgenetic Alopecia Patients: A Case-Control Study

This case-control study involving 30 male patients with androgenetic alopecia (AGA) and 30 healthy controls found significantly higher serum NF-κB levels in AGA patients, suggesting its potential as a novel biomarker for the condition. NF-κB levels showed a positive correlation with disease severity, duration, and age, but a negative correlation with BMI. The study demonstrated high diagnostic accuracy for NF-κB, with an AUC of 0.979, 93.3% sensitivity, and 90.0% specificity at a cutoff of 3.83 ng/mL. These results indicate that NF-κB may play a significant role in AGA pathogenesis and progression, and targeting it could offer new therapeutic options. However, the small sample size is a limitation, and further research is needed.