Evaluation of NF-κB as a Novel Serum Biomarker in Androgenetic Alopecia Patients: A Case-Control Study

    July 2025 in “ Arab Board Medical Journal ”
    Reem G.El-Garib Ali, Hanan Fathy Mohamed
    Studysummary This study found that patients with androgenetic alopecia had significantly higher serum NF-κB levels compared to controls, and these levels correlated with disease severity, suggesting NF-κB as a potential biomarker and therapeutic target.
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    Research cited in this study 15

    1. Immune and Non-Immune Interactions in the Pathogenesis of Androgenetic Alopecia Clinical Reviews in Allergy & Immunology · 2025
    2. Oxidative Stress in Hair Follicle Development and Hair Growth: Signaling Pathways, Intervening Mechanisms and Potential of Natural Antioxidants Journal of Cellular and Molecular Medicine · 2024
    3. NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications Signal transduction and targeted therapy · 2024
    4. Molecular Mechanisms of Hair Follicle Development The Scientific World JOURNAL · 2024
    5. Evaluation of Oxidative Stress Markers in Androgenetic Alopecia Patients Benha Journal of Applied Sciences · 2023
    6. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    7. Examination of Androgenetic Alopecia with Serum Biomarkers Journal of Cosmetic Dermatology · 2020
    8. The Impact of Oxidative Stress in Androgenic Alopecia in Women Postepy Dermatologii I Alergologii · 2020
    9. The Combination of Overweight and Smoking Increases the Severity of Androgenetic Alopecia International Journal of Dermatology · 2017
    10. Androgenetic Alopecia: A Review Endocrine · 2017
    11. Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles Scientific reports · 2017
    12. The Role of Oxidative Stress in Early-Onset Androgenetic Alopecia Journal of Cosmetic Dermatology · 2016
    13. Multi-Therapies in Androgenetic Alopecia: Review and Clinical Experiences Dermatologic Therapy · 2016
    14. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    15. Higher Body Mass Index Is Associated With Greater Severity of Alopecia in Men With Male-Pattern Androgenetic Alopecia in Taiwan: A Cross-Sectional Study Journal of The American Academy of Dermatology · 2013