Skin Microbiota Ameliorates Androgenetic Alopecia by Harmonizing Skin Immuno-Inflammatory Balance

    March 2026 in “ Brazilian Journal of Microbiology ”
    Yichen Cao, Xusheng Wu, Zixuan Huang … Hongbin Luo
    Studysummary This study found that restoring the skin microbiome significantly improved hair growth and skin condition in androgenic alopecia model mice by modulating the immune-inflammatory balance, highlighting the potential of bacterial-based therapies for hair loss.
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    Research cited in this study 14

    1. Nutritional and Microbial Strategies for Treating Acne, Alopecia, and Atopic Dermatitis Nutrients · 2024
    2. Efficacy of Probiotics in Hair Growth and Dandruff Control: A Systematic Review and Meta-Analysis Heliyon · 2024
    3. Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study Life · 2023
    4. The Gut and Skin Microbiome in Alopecia: Associations and Interventions PubMed · 2023
    5. Androgenetic Alopecia: Therapy Update Drugs · 2023
    6. The Skin Microbiome: Current Landscape and Future Opportunities International Journal of Molecular Sciences · 2023
    7. Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism Science Advances · 2023
    8. Advances in the Human Skin Microbiota and Its Roles in Cutaneous Diseases Microbial Cell Factories · 2022
    9. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    10. Characteristics of Healthy and Androgenetic Alopecia Scalp Microbiome: Effect of Lindera Strychnifolia Roots Extract as a Natural Solution for Its Modulation International Journal of Cosmetic Science · 2020
    11. Skin - A Vast Organ with Immunological Function (Review) Experimental and Therapeutic Medicine · 2020
    12. Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin Cell host & microbe · 2017
    13. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    14. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010