Clinical Translation of Microbiome Research in Alopecia Areata: A New Perspective

May 2022 in “ Cosmetics ”

Fabio Rinaldi, Anna Trink, Angela Papale, Giammaria Giuliani, Daniela Pinto

From the encyclopedia

autoimmune disorder causing patchy hair loss

vitamin you should probably be taking for general health might also help your hair a little

Studysummary This review explores the potential roles of the gut and skin microbiome in alopecia areata, suggesting topical and systemic strategies for managing the condition, but it reports no new clinical results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Characteristics of Healthy and Androgenetic Alopecia Scalp Microbiome: Effect of Lindera Strychnifolia Roots Extract as a Natural Solution for Its Modulation

research Characteristics of Healthy and Androgenetic Alopecia Scalp Microbiome: Effect of Lindera Strychnifolia Roots Extract as a Natural Solution for Its Modulation

2 citations , August 2020 in “International Journal of Cosmetic Science”

This study suggests that Lindera strychnifolia root extract may help restore a healthy microbial balance on the scalp in men with androgenetic alopecia after 83 days of treatment.

research Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata

134 citations , July 2020 in “Experimental dermatology”

This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.

research Predictive Metagenomic Profiling, Urine Metabolomics, And Human Marker Gene Expression As An Integrated Approach To Study Alopecia Areata

22 citations , April 2020 in “Frontiers in Cellular and Infection Microbiology”

This study found significant differences in scalp microbiome composition and volatile organic metabolites between individuals with alopecia areata and healthy controls, suggesting potential microbiome-related therapeutic interventions for hair growth disorders.

research Hair Regrowth Following Fecal Microbiota Transplantation in an Elderly Patient with Alopecia Areata: A Case Report and Review of the Literature

40 citations , September 2019 in “World journal of clinical cases”

In this case report, an 86-year-old man experienced new hair growth and color change in alopecia areata after receiving fecal microbiota transplantation for noninfectious diarrhea.

research Investigation on Microecology of Hair Root Fungi in Androgenetic Alopecia Patients

9 citations , June 2019 in “Mycopathologia”

This study found that the presence of Malassezia fungi in the scalp's hairy roots was more pronounced in individuals with androgenetic alopecia than in healthy controls, suggesting a potential link to the condition.

research Microbiome in the Hair Follicle of Androgenetic Alopecia Patients

26 citations , May 2019 in “PLOS ONE”

This study observed that hair follicles in hair loss patients had increased levels of Propionibacterium acnes, potentially linked to elevated immune response gene expression in miniaturized hair follicles.

research Scalp Bacterial Shift in Alopecia Areata

48 citations , April 2019 in “PloS one”

This study observed a microbial shift on the scalp of Alopecia areata patients, characterized by an increase in Propionibacterium acnes and a decrease in Staphylococcus epidermidis, compared to healthy controls.

research The Role of Vitamins and Minerals in Hair Loss: A Review

134 citations , December 2018 in “Dermatology and Therapy”

This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.

research Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health

65 citations , October 2018 in “Frontiers in cellular and infection microbiology”

This study observed that dandruff in Indian women is associated with a distinct scalp microbiome, including specific bacterial and unknown Malassezia species, with implications for nutrient homeostasis and cell-host adhesion pathways.

research Micronutrients in Hair Loss

10 citations , July 2018 in “Our Dermatology Online”

This research reviewed literature to evaluate the role of micronutrients in hair loss and hair growth, examining normal nutrient levels, their role in the hair follicle cycle, and their use in treatments, with data drawn from 92 peer-reviewed articles and reputable health organizations.

research An Investigation of Vitamin D Status in Alopecia Areata

37 citations , June 2018 in “Clinical and Experimental Medicine”

This study found that patients with alopecia areata had significant systemic inflammation and vitamin D deficiency, with both conditions more pronounced as disease severity increased.

research Alopecia Areata and the Gut: The Link Opens Up for Novel Therapeutic Interventions

48 citations , May 2018 in “Expert Opinion on Therapeutic Targets”

This review discusses how modern lifestyle factors affecting gut health may contribute to Alopecia Areata in genetically predisposed individuals, reporting no new results but suggesting the need for long-term interventions.

research Increased Prevalence of Vitamin D Deficiency in Patients with Alopecia Areata: A Systematic Review and Meta-Analysis

48 citations , April 2018 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This study found that individuals with alopecia areata had significantly lower serum vitamin D levels and a higher prevalence of vitamin D deficiency compared to people without the condition.

research Immune Privilege Collapse And Alopecia Development: Is Stress A Factor

51 citations , December 2017 in “Skin Appendage Disorders”

This review examines the literature on autoimmune hair loss disorders, highlighting the collapse of immune privilege and the potential role of neurogenic stress in this process, but reports no new clinical results.

research Correlation of Vitamin D and Vitamin D Receptor Expression in Patients with Alopecia Areata: A Clinical Paradigm

29 citations , December 2017 in “International Journal of Dermatology”

This study found that vitamin D deficiency in patients with alopecia areata was associated with greater disease severity and longer duration, but not with disease pattern or vitamin D receptor expression.

research The Role of Micronutrients in Alopecia Areata: A Review

63 citations , May 2017 in “American Journal of Clinical Dermatology”

This review found that patients with alopecia areata may have lower levels of vitamin D, zinc, and folate, but conflicting evidence precludes definitive clinical recommendations for micronutrient supplementation.

research Serum Vitamin D Level Is Related to Disease Severity in Pediatric Alopecia Areata

28 citations , April 2017 in “Journal of cosmetic dermatology”

This study found that while vitamin D deficiency is not the sole cause of alopecia areata, it may worsen the disease, suggesting supplementation could help in pediatric cases.

research Gut Microbiota Plays a Role in the Development of Alopecia Areata

10 citations , April 2017 in “Journal of Investigative Dermatology”

The gut microbiome affects the development of alopecia areata.

research Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin

192 citations , March 2017 in “Cell host & microbe”

The researchers reported that hair follicle development and commensal microbe colonization promote the accumulation of regulatory T cells in neonatal skin, with the Ccl20-Ccr6 pathway playing a key role in this process.

research Efficacy and Safety of Topical Calcipotriol in Management of Alopecia Areata: A Pilot Study

39 citations , January 2017 in “Dermatologic Therapy”

This study found that topical calcipotriol lotion resulted in hair regrowth in 59.1% of alopecia areata patients, with better response observed in those with lower serum vitamin D levels.

research Isolation and Quantification of Glycosaminoglycans from Human Hair Shaft

6 citations , January 2016 in “Annals of Dermatology”

This study found that glycosaminoglycan levels were higher in the occipital area of the hair shaft compared to the parietal area, with children showing higher levels than adults.

research Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata

62 citations , June 2015 in “The Journal of Dermatology”

This study found that patients with alopecia areata had higher levels of Th17 cells and lower levels of regulatory T cells compared to healthy controls, suggesting an immune imbalance in these patients.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

This study found that JAK inhibitors promote hair regrowth in both mice and human alopecia areata cases by blocking key immune pathways involved in disease development.

research Alopecia Areata: A Review

29 citations , June 2013 in “Journal of the Saudi Society of Dermatology & Dermatologic Surgery”

This review outlines the mechanisms, clinical features, and management strategies for alopecia areata and presents no new experimental findings.

research Successful Treatment of Alopecia Areata with Topical Calcipotriol

51 citations , January 2012 in “Annals of dermatology/Annals of Dermatology”

This case report describes a 7-year-old boy with alopecia areata and reduced vitamin D receptor expression whose condition improved after using calcipotriol, a strong vitamin D analog.

research Trichohyalin Is a Potential Major Autoantigen in Human Alopecia Areata

66 citations , July 2010 in “Journal of Proteome Research”

This study suggests that an immune response to trichohyalin and keratin 16 may contribute to the pathogenesis of alopecia areata.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

This study identified key genetic regions associated with alopecia areata, highlighting both acquired and innate immune involvement, with a novel link to the upregulation of ULBP ligands in autoimmune disease.

research Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack

253 citations , December 2007 in “Journal of Investigative Dermatology”

This study suggests that human hair follicles may actively suppress natural killer cells, which contrasts with the observed defects in NK cell regulation in alopecia areata.

research Abnormalities in the Hair Morphology of Patients with Some but Not All Types of Mucopolysaccharidoses

22 citations , March 2007 in “European journal of pediatrics”

This study found that scanning electron microscopy revealed considerable abnormalities in hair morphology in MPS I, II, IIIA, and IIIB patients, potentially related to heparan sulfate accumulation.

research Autoimmunity: Alopecia Areata

143 citations , January 2004 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the autoimmune nature of alopecia areata, potential therapeutic targets, and highlights the need for further studies on immunomodulatory treatments and genetic factors, but it reports no new clinical results.