S100A8 Induces Cyclophosphamide-Induced Alopecia via NCF2/NOX2-Mediated Ferroptosis

    February 2025 in “ Free Radical Biology and Medicine ”
    Wenping Xu, Yujie Li, Sheng Wan … Xiuzu Song
    Studysummary In a mouse model of chemotherapy-induced alopecia, this study found that inhibiting the protein S100A8 with paquinimod alleviated hair loss and reduced oxidative stress and ferroptosis, suggesting a potential therapeutic strategy for managing this side effect in chemotherapy patients.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 10

    1. 1,25-(OH)2D3 Promotes Hair Growth by Inhibiting NLRP3/IL-1β and HIF-1α/IL-1β Signaling Pathways The Journal of Nutritional Biochemistry · 2024
    2. Effect of N-Acetylcysteine on Hair Follicle Changes in Mouse Model of Cyclophosphamide-Induced Alopecia: Histological and Biochemical Study Histochemistry and cell biology · 2024
    3. Cytoprotective Role of Human Dental Pulp Stem Cell-Conditioned Medium in Chemotherapy-Induced Alopecia Stem cell research & therapy · 2024
    4. Identification of Ferroptosis-Related Biomarkers in Alopecia Areata Through Machine Learning Scientific reports · 2024
    5. Transcriptome Analysis of Frontal Fibrosing Alopecia Revealed Involvement of Immune Cells and Ferroptosis Skin research and technology · 2024
    6. CFTR Potentiator Ivacaftor Protects Against Noise-Induced Hair Cell Loss by Increasing Nrf2 and Reducing Oxidative Stress Biomedicine & Pharmacotherapy · 2023
    7. Clinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors JAMA Dermatology · 2021
    8. Peroxisome Proliferator-Activated Receptor-γ Signalling Protects Hair Follicle Stem Cells from Chemotherapy-Induced Apoptosis and Epithelial-Mesenchymal Transition British journal of dermatology/British journal of dermatology, Supplement · 2021
    9. CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia EMBO Molecular Medicine · 2019
    10. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013