miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells
December 2020
in “Frontiers in cell and developmental biology”
TLDR miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.
This study investigated the role of extracellular vesicles (EVs) from human dermal papilla cells (DPCs) in hair growth. It was found that low-passage DP-EVs promoted hair follicle elongation and cell proliferation more effectively than high-passage DP-EVs. High-throughput miRNA sequencing identified miR-140-5p as highly enriched in low-passage DP-EVs, which directly repressed BMP2, a key gene in the BMP/TGF-β signaling pathways. The study concluded that miR-140-5p in DP-EVs plays a critical role in hair growth by promoting the proliferation of outer root sheath and hair matrix cells, making it a potential therapeutic target for alopecia.
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