TLDR Male pattern baldness involves hormones and cell signals affecting hair growth.
This 12-year-old scientific paper explores the molecular basis of androgenetic alopecia (AGA), also known as male pattern baldness. The paper discusses the role of dihydrotestosterone (DHT) and its interaction with the androgen receptor (AR) in the pathogenesis of AGA. The paper also explores the role of paracrine mediators from dermal papilla cells, such as TGF-B and DKK-1, in the suppression of hair growth and early catagen induction in AGA. The paper concludes that the mechanism of AGA is tightly regulated at each step in the androgen signaling pathway and that more pathogenic mediators will likely be identified in the future, providing new therapeutic targets.View this study on doi.org →
Dutasteride 0.5 mg daily improves hair growth safely in men with hair loss.
A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.
Dutasteride more effective for hair growth, but has more side effects than finasteride.
Androgen hormones cause hair follicle scarring in hair loss, and finasteride helps reduce it.
Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.
TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.
Gene differences may affect baldness treatment response in Korean men.
Finasteride potentially treats hair loss by reducing DHT production.
RU58841, a nonsteroidal anti-androgen, showed potential as a topical treatment for hair loss, increasing hair density, thickness, and length without systemic side effects in Stumptailed Macaques.
Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.
Male pattern baldness involves hormones and cell signals affecting hair growth.
AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.