Effects of EGF on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles
TLDR EGF makes hair follicles grow longer but stops hair production.
The study investigated the effects of epidermal growth factor (EGF) on isolated human hair follicles. It was found that EGF significantly stimulated the elongation of hair follicles but inhibited hair fiber production. Light microscopy revealed that EGF caused thickening and vacuolation in the lower outer root sheath cells and induced upward migration of matrix cells, forming a 'club hair'-like structure. Autoradiography showed that EGF inhibited DNA synthesis in matrix cells but stimulated it in the outer root sheath. The study concluded that EGF might induce a 'catagen-like' effect by disrupting normal proliferation and migration patterns, suggesting that outer root sheath cells could migrate downward under certain conditions.
View this study on jidonline.org →
Cited in this study
research Inductive Properties of Hair Follicle Cells
Hair growth can be induced by certain cells found at the base of hair follicles, and these cells may also influence hair development and regeneration.
research Hair Growth Induction: Roles of Growth Factors
EGF and FGF help hair growth by affecting cell differentiation and fiber growth.
Related
research Hair-cycle dependent differential expression of ADAM 10 and ADAM 12
ADAM 10 and ADAM 12 proteins are involved in different stages of hair growth and could be targets for treating hair disorders.
research Effects of EGF on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles
EGF makes hair follicles grow longer but stops hair production.