Sustained release of dermal papilla-derived extracellular vesicles from injectable microgel promotes hair growth
January 2020
in “Theranostics”
TLDR Injecting a special gel with human protein particles can help hair grow.
The 2020 study explored the use of human dermal papilla-derived extracellular vesicles (DP-EVs) encapsulated in partially oxidized sodium alginate (OSA) hydrogels to promote hair growth. The OSA-EVs, measuring about 100 µm, provided a sustained-release system that improved the stability and retention of vesicular proteins and EVs, both in vitro and in vivo. The release of DP-EVs from the hydrogel stimulated hair matrix cell proliferation, extended the anagen phase in cultured human hairs, and sped up hair regrowth in mice post-depilation. This effect was likely due to the increased expression of hair growth-promoting molecules like Wnt3a and ß-catenin, and decreased expression of the inhibitory molecule BMP2. The study concluded that OSA hydrogels could enhance the therapeutic effects of DP-EVs, presenting a potential new treatment for alopecia. The study involved experiments with human hair follicles from 5 women aged 35-45 and 32 mice divided into groups of 8, with results showing statistical significance.
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