Human hair follicles contain two forms of ATP‐ sensitive potassium channels, only one of which is sensitive to minoxidil
June 2008
in “The FASEB Journal”
TLDR One minoxidil-sensitive potassium channel exists in human hair follicles.
This document discusses a study that found human hair follicles contain two forms of ATP-sensitive potassium channels, but only one of them is sensitive to minoxidil, a drug used to treat hair loss. The study suggests that understanding the specific forms of these channels present in hair follicles could lead to the development of more effective hair growth therapies. The study also found that KATP channel blockers, such as tolbutamide, may be able to be harnessed to reduce hair growth, ideally in a topical formulation.
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research Management of Hair Loss
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research Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle
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research Minoxidil: mechanisms of action on hair growth
Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.
research A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men
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research Minoxidil-Induced Hair Growth is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil
Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.
research Changes in hair weight and hair count in men with androgenetic alopecia, after application of 5% and 2% topical minoxidil, placebo, or no treatment
Minoxidil increases hair weight and count temporarily in men with hair loss.
research Minoxidil increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity of cultured human dermal papilla cells from balding scalp
Minoxidil boosts enzymes that help hair growth.
research The induction by topical minoxidil of increased fenestration in the perifollicular capillary wall
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research Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells
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research Effects of Self-Perceived Hair Loss in a Community Sample of Men
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research Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes
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research Whole Hair Follicle Culture
research Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil
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research Five-year follow-up of men with androgenetic alopecia treated with topical minoxidil
Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.
research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture
Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.
research The history of the development of minoxidil
Minoxidil was first made for high blood pressure, but it was later found to help hair growth.
research Long-term follow-up of men with male pattern baldness treated with topical minoxidil
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research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography
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Related
research Human hair follicles contain two forms of ATP‐ sensitive potassium channels, only one of which is sensitive to minoxidil
One minoxidil-sensitive potassium channel exists in human hair follicles.
research Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for their Modes of Action in Hair Follicles
Potassium channel openers like minoxidil help hair grow by acting on hair follicles.