Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice
November 2017
in “Scientific Reports”
TLDR Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.
The 2017 study investigated the effects of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) on hair growth, both in vitro and in vivo. In vitro, MSC-EVs were found to increase proliferation and migration of human dermal papilla cells, as well as upregulate growth factors such as VEGF and IGF-1. In vivo, intradermal injections of MSC-EVs into C57BL/6 mice, with a group size of 6 mice for MSC-EV treatment, 5 mice for the PBS control, and 6 mice for the 3% minoxidil positive control, promoted the transition of hair follicles from the telogen phase to the anagen phase, which is indicative of active hair growth. The treatment was comparable to minoxidil and did not cause toxicity. The study concluded that MSC-EVs could be a potential non-toxic treatment for hair regrowth and activating hair follicles to enter the growth phase.
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