Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation
January 2019
in “International journal of biological sciences”
TLDR Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.
The study demonstrated that dermal papilla cell-derived exosomes (DPC-Exos) promoted hair follicle (HF) growth by inducing the anagen stage and delaying the catagen stage. It was found that DPC-Exos attached to hair follicle stem cells (HFSCs) and induced their differentiation. High-throughput sequencing identified 111 differentially expressed miRNAs in DPC-Exos, with the top 34 miRNAs suggesting roles in cellular signal transduction, fatty acid expression regulation, and cellular communication. Specifically, miR-22-5p was found to negatively regulate HFSC proliferation by targeting the LEF1 gene, proposing the miR-22-5p-LEF1 axis as a novel pathway for regulating HFSC proliferation.
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