Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair‐inductive capacity of cultured dermal papilla spheres
July 2019
in “Experimental Dermatology”
TLDR Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.
In 2019, Prof. Young-Kwan Sung led a study that discovered exosomes derived from human dermal papilla cells (DP cells) can stimulate hair growth and regeneration. The research showed that these exosomes, when derived from 3D cultured DP cells, increased the proliferation of DP cells and outer root sheath cells, and boosted the expression of growth factors in DP cells. They also extended the length of the hair shaft in cultured human hair follicles and triggered the active growth phase of hair follicles in mice. When used in human DP spheres, these exosomes enhanced hair follicle neogenesis. The study concluded that these exosomes could potentially be used in therapeutic strategies for hair loss.
View this study on onlinelibrary.wiley.com →
Cited in this study
research Regulation of hair follicle development by exosomes derived from dermal papilla cells
Exosomes from dermal papilla cells can help grow hair and might treat hair loss.
research Activin A-induced signalling controls hair follicle neogenesis
Activin A is important for creating new hair follicles.
research Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth
Growing human skin cells in a 3D environment can stimulate new hair growth.
research Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay
Forming spheres boosts the ability of certain human cells to create hair follicles when mixed with mouse skin cells.
Related
research Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase
research Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling
Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
research Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair‐inductive capacity of cultured dermal papilla spheres
Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.