Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents
May 2008
in “Journal of Investigative Dermatology”
TLDR Mice hair growth patterns get more complex with age and can change with events like pregnancy or injury.
In the 2008 study, Plikus and Chuong investigated hair cycle domain patterns and regenerative hair waves in living rodents, specifically mice. They used non-invasive methods to track hair follicle cycling and found that as mice age, their hair cycle patterns become more complex, with follicles cycling in smaller, non-synchronized groups. The study, which involved long-term monitoring of over 25 mice, showed that hair cycle domain patterns can be reset by physiological events like pregnancy or skin trauma, and are not permanently fixed in their structure or "memory." The researchers proposed a topographic sector map to describe these patterns and differentiated between transitory regenerative hair waves and permanent developmental waves. They concluded that the complexity of the hair cycle should be recognized in hair research and that their techniques could be integrated into experimental designs, suggesting the potential for future studies to explore the interactive behavior of hair follicles and the molecular mechanisms underlying hair cycle wave propagation.
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