Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen
May 2003
in “American Journal of Pathology”
TLDR Prolactin affects hair growth cycles and can cause early hair follicle regression.
The document from May 1, 2003, details a study that found prolactin (PRL) and its receptor (PRLR) are expressed in murine hair follicle epithelium in a hair cycle-dependent manner, with increased expression during the anagen and catagen phases. The study revealed that PRL can induce premature catagen development, suggesting a direct role in modulating the hair cycle. Using real-time PCR and Ki-67 immunohistochemistry, the researchers showed that PRL treatment reduced the number of proliferating cells in the hair bulb and maintained more follicles in the telogen phase. These findings suggest that PRL acts locally within hair follicles, potentially influencing hair growth abnormalities in conditions with elevated PRL levels. The document does not provide the number of mice used in the study.
View this study on ajp.amjpathol.org →
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