Mechanism Exploration of the Combined Use of Minoxidil with Natural Compounds Ginsenoside Rg3 and Glycyrrhizic Acid for Enhancing Androgenic Alopecia Therapy

    December 2025 in “ Journal of Drug Delivery Science and Technology ”
    Hao Sui, Shuhui Kang, Gang Wang … Qingping Tian
    Studysummary In mouse studies, this research found that combining ginsenoside Rg3 and glycyrrhizic acid with minoxidil improved treatment outcomes for androgen alopecia by addressing both symptoms and root causes, notably activating the Wnt/β-catenin pathway and promoting hair follicle cell proliferation.
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    Research cited in this study 21

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    2. Minoxidil Cyclodextrin Inclusion Complex-Loaded Microemulsions and Transfersomes for Androgen Alopecia Treatment: A Comparative Study Drug Delivery and Translational Research · 2025
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    4. Minoxidil Cyclodextrin Complexes and Their Inclusion in Transfersomes for the Enhancement of Therapeutic Effect on Androgenic Alopecia Journal of Drug Delivery Science and Technology · 2024
    5. Pilose Antler Extract Promotes Hair Growth in Androgenic Alopecia Mice by Promoting the Initial Anagen Phase Biomedicine & pharmacotherapy · 2024
    6. Synergistic Therapeutic Effect of Ginsenoside Rg3 Modified Minoxidil Transfersomes on Androgenic Alopecia in C57BL/6 Mice International Journal of Pharmaceutics · 2024
    7. Dissolvable Microneedles Loaded with Ginsenoside Rg3 Liposome: A Transdermal Delivery Approach for Alopecia Treatment Regenerative Biomaterials · 2024
    8. pH Stimulus-Responsive Hybrid Nanoparticles: A System Designed for Follicular Delivery of Brazilian Plant-Derived 5-Alpha-Reductase Enzyme Inhibitors International Journal of Pharmaceutics · 2023
    9. Studying Hair Growth Cycle and Its Effects on Mouse Skin Journal of Investigative Dermatology · 2023
    10. The Preparation of High Minoxidil Loaded Transfersomes and Its Gel for Effective Topical Treatment of Alopecia Journal of Drug Delivery Science and Technology · 2023
    11. Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia Journal of Dermatological Treatment · 2022
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    15. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
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    19. Androgenetic Alopecia: A Review Endocrine · 2017
    20. Enhancement of Human Hair Growth Using Ecklonia Cava Polyphenols Annals of Dermatology · 2016
    21. Effects of Ginseng Rhizome and Ginsenoside Ro on Testosterone 5α-Reductase and Hair Regrowth in Testosterone-Treated Mice Phytotherapy Research · 2011