Delivery of Minoxidil Encapsulated in Cyclodextrins with Photoacoustic Waves Enhances Hair Growth

    June 2024 in “ European Journal of Pharmaceutics and Biopharmaceutics ”
    Sofia Melo‐Guímaro, Renato M. S. Cardoso, Catarina S. Lobo, Diogo A. Pereira, Carla Varela, João A. Santos, Luís G. Arnaut, Luís G. Arnaut, Luís G. Arnaut
    TLDR Using photoacoustic waves to deliver minoxidil improves hair growth effectively and safely.
    The study explored using photoacoustic waves to enhance the delivery of minoxidil encapsulated in β-cyclodextrins (MNX@β-CD) for treating androgenetic alopecia (AGA). Conducted on male Sprague-Dawley rats, the research demonstrated that active delivery with photoacoustic waves significantly improved hair regrowth, achieving 86.2% coverage within 8 days, compared to lower regrowth with commercial Minox®2 and passive MNX@β-CD. This method increased transdermal flux by 3-fold and did not significantly affect blood pressure, indicating minimal systemic absorption. The findings suggest that this approach could improve patient compliance, reduce side effects, and accelerate hair regrowth in AGA treatment.
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