August 2023 in “Drug Design Development and Therapy” Minoxidil may work for hair loss by reducing androgen sensitivity and altering hormone-related enzymes.
June 2023 in “Skin Research and Technology” Using platelet-rich plasma injections and 5% minoxidil topically can safely and effectively treat mild-to-moderate male pattern baldness.
There are many treatments for common hair loss, but more trials are needed to decide which are best.
May 2023 in “Clinical, Cosmetic and Investigational Dermatology” The document reviews current treatments and unmet needs for androgenetic alopecia (AGA), emphasizing the efficacy and limitations of existing therapies like minoxidil, finasteride, and low-level laser therapy (LLLT). Minoxidil and finasteride are effective but have compliance and side effect issues, while LLLT is a promising non-invasive option. Combination therapies, such as PRP with microneedling or minoxidil, show better outcomes than monotherapies. The review highlights the need for more personalized and effective treatments, as well as robust clinical trials to establish standardized protocols and address gaps in AGA management.
April 2023 in “Dermatology and therapy” This study on 400 patients with androgenetic alopecia (AGA) found a high discontinuation rate of 86.3% for topical minoxidil (TM), primarily due to side effects reported by 46.5% of patients, including scalp itching, facial hair, and increased hair loss. Longer treatment duration (over 1 year) and perceived improvement significantly reduced the likelihood of discontinuation. The study emphasizes the need for patient education on TM's side effects and the importance of using it for at least 12 months to evaluate its efficacy.
January 2023 in “Journal of pharmaceutical sciences” Thicker minoxidil solutions work better and need less frequent application.
1 citations,
June 2022 in “Journal of Cutaneous and Aesthetic Surgery” 5 citations,
April 2022 in “Pharmaceutics” 
May 2021 in “The Journal of clinical and aesthetic dermatology” Most women with hair loss using 5% topical Minoxidil are satisfied with the treatment, but hair loss still affects their daily habits and social life.
6 citations,
May 2020 in “Pharmacology Research & Perspectives” A new gel form of minoxidil is equally effective for hair growth and safer for the heart and other organs than the traditional solution.
40 citations,
January 2018 in “Pharmaceutics” Eucalyptol and oleic acid in nanoemulsions improve minoxidil delivery to hair follicles, potentially enhancing hair loss treatment.
2 citations,
January 2018 in “Journal of Cosmetic and Laser Therapy” JetPeel-assisted minoxidil improves hair density and thickness more than minoxidil alone.
19 citations,
January 2018 in “European Journal of Pharmaceutics and Biopharmaceutics” The gel made of minoxidil and hydroxypropyl-β-cyclodextrin improves hair growth and is good for long-term use.
25 citations,
October 2015 in “Colloids and Surfaces B: Biointerfaces” Iontophoresis improves minoxidil delivery to hair follicles for hair loss treatment.
18 citations,
May 2015 in “Drug Development and Industrial Pharmacy” New gel formulas without ethanol and propylene glycol, containing a minoxidil-methyl-β-cyclodextrin complex, have been created for treating hair loss.
24 citations,
May 2013 in “Drug Design Development and Therapy” Multimodal minoxidil microemulsion is more effective in treating hair loss than minoxidil alone.
55 citations,
February 2010 in “Journal of Pharmaceutical Sciences” Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.
268 citations,
July 2009 in “International Journal of Pharmaceutics” Niosomes improve minoxidil skin delivery for hair loss treatment.
28 citations,
April 2008 in “Journal of Inclusion Phenomena and Macrocyclic Chemistry” Minoxidil mixed with β-cyclodextrin improves solubility and gradual release.
24 citations,
January 2003 in “Drug Delivery” Minoxidil-containing vesicles improve hair growth.
370 citations,
September 1999 in “The New England Journal of Medicine” Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.
58 citations,
July 1986 in “Journal of The American Academy of Dermatology” Lowest effective minoxidil concentration is 1%, but 2% works better for male pattern baldness.
