In Vitro and In Vivo Scalp Retention and Penetration of 99mTc-Minoxidil Solution

    September 2022 in “ Journal of pharmaceutical sciences ”
    Gargi Arora, Abha Mishra, G Gaurav, Nilesh Chandra, Prashant Kesharwani, Gaurav Jain
    Image of study
    TLDR Thicker minoxidil solutions work better and need less frequent application.
    The study evaluated the retention and penetration of radiolabeled minoxidil (5% w/v) on ex vivo skin and in vivo scalp using three formulations. Formulation C, which included 10% hydroxypropyl cellulose (HPC), showed significantly higher ex vivo retention and permeation compared to formulations with just the vehicle or with 10% propylene glycol (PG). In vivo results confirmed that formulation C had nearly 2.8-fold and 2.2-fold higher scalp penetration than formulations A and B, respectively, after 8 hours. The absence of minoxidil in systemic circulation indicated safety. The study concluded that increasing the contact time of minoxidil with the scalp by enhancing viscosity improves efficacy and reduces the frequency of application.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    6 / 1000+ results

      community Alternatives to Minox for pet safety

      in Minoxidil  2 upvotes 2 months ago
      The conversation discusses alternatives to minoxidil for beard growth, focusing on a product called Neofollics Beard Growth Serum, which claims to be effective without using minoxidil. Concerns are raised about its ingredients and effectiveness, especially considering pet safety.

      community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

      in Research/Science  3 upvotes 1 month ago
      Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

      community What ketoconazole shampoo do you use?

      in Ketoconazole  8 upvotes 9 months ago
      Nizoral is commonly used for hair loss and dandruff, but it can cause dryness; users often pair it with conditioners or alternative shampoos. Some also use finasteride, minoxidil, and red light therapy for hair care.

      community Minoxidil and Finastride topical solution 2 months update

      in Minoxidil  6 upvotes 4 days ago
      A 34-year-old woman has been using a topical solution of 5% Minoxidil and 0.1% Finasteride since January 2026 to address hair thinning caused by PCOS and poor nutrition. She reports ongoing hair shedding but has improved her diet with whole foods and supplements.

      community Hair partition and Minoxidil Application

      in Minoxidil  2 upvotes 1 week ago
      A user is experiencing hair loss and is using Morr F 5% Minoxidil, Finasteride Lipid Solution, ketoconazole shampoo, and biotin tablets. They seek advice on the correct application method and hair partitioning.

    Related Research

    1 / 1 results