In Vitro and In Vivo Scalp Retention and Penetration of 99mTc-Minoxidil Solution

    September 2022 in “ Journal of pharmaceutical sciences ”
    Gargi Arora, Abha Mishra, G Gaurav … Gaurav Jain
    Studysummary This study found that adding hydroxypropyl cellulose to minoxidil formulations significantly increased scalp retention and penetration compared to other formulations, potentially leading to reduced application frequency and improved efficacy.
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    Research cited in this study 17

    1. The 'Bald' Phenotype (Androgenetic Alopecia) Is Caused by the High Glycemic, High Cholesterol, and Low Mineral 'Western Diet' Trends in Food Science and Technology · 2021
    2. Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence Clinical, Cosmetic and Investigational Dermatology · 2021
    3. Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls Clinical Interventions in Aging · 2021
    4. Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia International Journal of Molecular Sciences · 2020
    5. Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies Experimental Dermatology · 2020
    6. Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway Journal of Dermatological Treatment · 2020
    7. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    8. Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation Journal of Dermatological Treatment · 2019
    9. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    10. Off-Label Use of Topical Minoxidil in Alopecia: A Review American Journal of Clinical Dermatology · 2019
    11. Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery Medicines · 2018
    12. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    13. Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells International Journal of Trichology · 2018
    14. Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect Journal of Dermatological Science · 2011
    15. Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro Journal of Pharmaceutical Sciences · 2009
    16. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    17. The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats Journal of Dermatology · 1990

    Related research 1

    1. Topical Minoxidil (3%) in Extensive Alopecia Areata, Including Long-Term Efficacy Journal of The American Academy of Dermatology · 1987