Minoxidil: a review of its pharmacological properties and therapeutic use.
October 1981
in “Drugs”
TLDR Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.
This document is a review of the pharmacological properties and therapeutic use of minoxidil, a drug used to treat hypertension. Minoxidil is effective in treating severe hypertension, including refractory hypertension and hypertension in patients with chronic renal failure. However, it can also cause adverse effects such as hypertrichosis and acute cardiomyopathy. The drug is only approved for use in patients who do not respond to conventional antihypertensive regimens. The review concludes that minoxidil is a useful therapeutic option for severe hypertension, but its use should be carefully monitored due to its potential side effects.
View this study on link.springer.com →
Cited in this study
research Minoxidil in Severe Hypertension
Minoxidil lowers blood pressure and causes hair growth, with some side effects.
research MINOXIDIL-HAEMODYNAMIC AND CLINICAL EXPERIENCES WITH A NEW PERIPHERAL VASODILATOR
Minoxidil helps control blood pressure but has side-effects, so it's not for everyone.
research Renal Function During Long-Term Treatment of Hypertension with Minoxidil
Long-term use of minoxidil for high blood pressure can delay kidney failure in some patients and improve kidney function in others with severe hypertension.
research Minoxidil and the Treatment of Severe Hypertension
Minoxidil lowers blood pressure effectively but may cause unwanted hair growth and other side effects.
research Minoxidil: right atrial cardiac pathology in animals and in man.
Minoxidil may cause heart issues in animals and humans.
research Pericardial Disorders Occurring During Open-Label Study of 1,869 Severely Hypertensive Patients Treated with Minoxidil
Minoxidil doesn't increase pericardial disorder risk, but may cause fluid accumulation.
research Pharmacology and Pharmacokinetics of Minoxidil
Minoxidil treats high blood pressure and side effects can be managed.
research Hypertrichosis due to minoxidil
Minoxidil causes excessive hair growth in almost all patients.
research Treatment of Severe Hypertension with Minoxidil: Advantages and Limitations
Minoxidil effectively controls blood pressure but side effects may limit its use.
research Acute cardiomyopathy induced by the vasodilating antihypertensive agent minoxidil
Minoxidil can cause heart muscle damage in dogs.
research Long-Term Clinical Effects, Bioavailability, and Kinetics of Minoxidil in Relation to Renal Function
research Long-Term Treatment of Refractory Hypertensive Patients With Minoxidil
Minoxidil controls blood pressure but may cause kidney damage and needs diuretics to prevent swelling.
research Minoxidil Therapy in Refractory Hypertension Analysis of 155 Patients
Minoxidil lowers blood pressure effectively but may cause side effects.
research Minoxidil for severe hypertension after failure of other hypotensive drugs.
Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.
research Management of severe childhood hypertension with minoxidil: A controlled clinical study
Minoxidil helps lower blood pressure in kids with severe hypertension, but may cause temporary excessive hair growth.
research Minoxidil therapy in children with severe hypertension
Minoxidil helps lower high blood pressure in kids, but can cause fluid retention and hair growth.
research Minoxidil-induced hypertrichosis: treatment with calcium thioglycolate depilatory.
Minoxidil, a blood pressure drug, can cause excessive hair growth, but this can be successfully treated with a hair removal agent called calcium thioglycolate.
research The effects of minoxidil on pulmonary and systemic hemodynamics in hypertensive man.
Minoxidil lowers blood pressure and increases heart efficiency, but may raise lung artery pressure in some people.
research Toxicologic studies with the hypotensive agent minoxidil
Minoxidil is mostly safe, but high doses can cause electrolyte imbalances and heart issues in dogs.
research Effect of minoxidil on blood pressure and hemodynamics in severe hypertension
research Long-term treatment of severe hypertension with minoxidil, propranolol and furosemide.
Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.
research Minoxidil in severe hypertension: Value when conventional drugs have failed
Minoxidil effectively controls blood pressure in severe cases, but may cause fluid retention and edema.
research Metabolism of Minoxidil, a New Hypotensive Agent 11: Biotransformation following Oral Administration to Rats, Dogs, and Monkeys
Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.
research A method for achieving blood pressure control expeditiously with oral minoxidil
Oral minoxidil effectively controls blood pressure quickly and safely.
research Control plasma renin activity and changes in sympathetic tone as determinants of minoxidil-induced increase in plasma renin activity.
Minoxidil boosts plasma renin activity, influenced by control plasma renin activity and changes in sympathetic tone.
research Differential effects of propranolol on heart rate and plasma renin activity in patients treated with minoxidil
Propranolol affects heart rate and renin levels in minoxidil-treated patients.
research Minoxidil — An Alternative to Nephrectomy for Refractory Hypertension
Minoxidil effectively lowers blood pressure with few side effects.
research Pharmacologic properties of minoxidil: a new hypotensive agent.
Minoxidil is a new drug that lowers blood pressure.
research Minoxidil in severe hypertension with renal failure
Minoxidil effectively lowers blood pressure without major side effects.
research Pharmacokinetic studies of minoxidil
Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.
research Tissue distribution and hypotensive effects of minoxidil in normotensive rats.
Minoxidil lowers blood pressure and spreads throughout the body in normal rats.