Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome

    January 2016 in “ Skin appendage disorders ”
    Raymond Fertig, Jerry Shapiro, Wilma F. Bergfeld, Antonella Tosti
    Studysummary This review examines medical literature on postfinasteride syndrome and reports no new results; the authors call for more controlled studies on permanent sexual dysfunction and mood changes linked to 5-alpha-reductase inhibitors.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 26

    1. Emotional Consequences of Finasteride: Fool’s Gold American Journal of Men's Health · 2016
    2. An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia International Journal of Andrology · 2016
    3. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    4. A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long-Term Side Effects After Finasteride Discontinuation International Journal of Biological Markers · 2014
    5. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    6. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    7. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer, and Depression Korean Journal of Urology · 2014
    8. Regional Difference in Sebum Production by Androgen Susceptibility in Human Facial Skin Experimental Dermatology · 2013
    9. Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
    10. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    11. The Role of Androgen and Androgen Receptor in Skin-Related Disorders Archives of Dermatological Research · 2012
    12. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    13. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    14. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    15. Finasteride and Male Breast Cancer: Does the MHRA Report Show a Link? PubMed · 2010
    16. The Effect of 5-Reductase Inhibitors on Erectile Function International Journal of Andrology · 2008
    17. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007
    18. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    19. Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders Pharmacology, Biochemistry and Behavior · 2006
    20. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    21. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia The New England Journal of Medicine · 2003
    22. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
    23. Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice PubMed · 1999
    24. The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1998
    25. Age-Related Changes in Brain and Pituitary 5α-Reductase with Finasteride (Proscar) Treatment Neurobiology of Aging · 1995
    26. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992

    Related research 9

    1. Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors Sexual medicine reviews · 2018
    2. The Impact of 5α-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health Current Urology Reports · 2018
    3. Sexual Side Effects of 5-Alpha-Reductase Inhibitors Finasteride and Dutasteride: A Comprehensive Review Dermatology Online Journal · 2017
    4. Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome Skin appendage disorders · 2016
    5. Side Effects of 5-Alpha Reductase Inhibitors: A Comprehensive Review Sexual medicine reviews · 2013
    6. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    7. 5-Alpha Reductase Inhibitors and Erectile Dysfunction: The Connection The Journal of Sexual Medicine · 2008
    8. Finasteride in the Treatment of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2004
    9. Finasteride in the Treatment of Alopecia Expert Opinion on Pharmacotherapy · 2004