TLDR lncRNA MRPS28 regulates hair follicle development in cashmere goats, affecting cashmere quality.
This study identifies lncRNA MRPS28 as a key regulator in the development of secondary hair follicles in cashmere goats, which affects cashmere yield and quality. lncRNA MRPS28, transcribed from the intron region of the MRPS28 gene, inhibits dermal fibroblast proliferation and migration while promoting apoptosis. It functions as a competing endogenous RNA by sponging chi-miR-145-5p, which alleviates its suppression on the target gene NUAK1, thereby inhibiting dermal papilla structure formation and affecting hair follicle morphogenesis during the embryonic period. These findings offer new insights into the regulatory network of hair follicle development and potential strategies for breeding improved cashmere goat strains.
November 2023 in “Animal Bioscience” miR-133a-3p and miR-145-5p help goat hair follicle stem cells differentiate by controlling NANOG and SOX9.
2 citations
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September 2022 in “Frontiers in veterinary science” Certain long non-coding RNAs are important for the growth of hair follicles in Inner Mongolian cashmere goats.
7 citations
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September 2022 in “International journal of molecular sciences” The research found that the molecule lncRNA-H19 helps hair follicle cells grow by affecting certain cell pathways in cashmere goats.
May 2022 in “Frontiers in Cell and Developmental Biology” miR-29a-5p prevents the formation of early hair structures by targeting a gene important for hair growth and is regulated by a complex network involving lncRNA627.1.
22 citations
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April 2020 in “Scientific reports” Changthangi goats have specific genes that help produce Pashmina wool.
11 citations
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March 2020 in “Cellular Signalling” XIST RNA helps regenerate hair follicles by targeting miR-424 and activating hedgehog signaling.
11 citations
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June 2017 in “Asian-Australasian journal of animal sciences” Fox genes are important for hair growth and development in cashmere goats.
127 citations
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March 2016 in “PLoS ONE” Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.
