Laser-Assisted Exosome Delivery with Fractional CO2 Laser: A Pilot Two-Case Report and Narrative Review

September 2025 in “ Cosmetics ”

Alessandro Clementi, Fortunato Cassalia, Giovanni Cannarozzo, Luca Guarino, Elena Zappia, Luigi Bennardo, Roberto Mazzetto, Andrea Danese, Caterina Longo, Steven Paul Nisticò

TLDR Laser-Assisted Exosome Delivery showed early skin improvement without side effects, but more research is needed.

This pilot study introduces Laser-Assisted Exosome Delivery (LAED) using a fractional CO2 laser, combined with exosomes, to treat skin conditions. It involved two cases: a 62-year-old man with acne scars and a 68-year-old woman with photoaging-related discoloration. Both patients showed early clinical improvement, with the man experiencing smoother scars and the woman seeing a 30% reduction in pigmentation. Recovery times were shorter, and no adverse events were reported. Despite promising results, the study's small sample size and non-comparative nature mean that further research with larger, controlled trials is needed to confirm LAED's efficacy.

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