Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells via Anagen-Activating Signaling Pathways

    December 2018 in “ Biological & Pharmaceutical Bulletin ”
    Hoon-Seok Yoon, Jingoo Kang, Sung Min Kim … Hee‐Kyoung Kang
    Studysummary In this study, norgalanthamine was found to stimulate hair growth in cultured rat dermal papilla cells by activating the ERK 1/2, PI3K/AKT, and Wnt/β-catenin signaling pathways.
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    Research cited in this study 11

    1. Undariopsis Peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways Marine Drugs · 2017
    2. Effect of Sinapic Acid on Hair Growth Promotion in Human Hair Follicle Dermal Papilla Cells via Akt Activation Archives of Dermatological Research · 2017
    3. Promotion Effect of Apo-9'-Fucoxanthinone from Sargassum Muticum on Hair Growth via the Activation of Wnt/β-Catenin and VEGF-R2 Biological & Pharmaceutical Bulletin · 2016
    4. The Hair Growth-Promoting Effect of Rumex Japonicus Houtt. Extract Evidence-based Complementary and Alternative Medicine · 2016
    5. Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles Annals of Dermatology · 2015
    6. Mammalian Target of Rapamycin Complex 1 (mTORC1) May Modulate the Timing of Anagen Entry in Mouse Hair Follicles Experimental dermatology · 2012
    7. Promotion Effect of Norgalanthamine, a Component of Crinum Asiaticum, on Hair Growth European Journal of Dermatology · 2010
    8. The Hair Cycle Journal of Cell Science · 2006
    9. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    10. Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle Journal of Dermatological Science · 2004
    11. Transfection of Rat Dermal Papilla Cells with a Gene Encoding a Temperature-Sensitive Polyomavirus Large T Antigen Generates Cell Lines Retaining a Differentiated Phenotype Journal of Cell Science · 1994