Mechanisms of Crinum Asiaticum Var. Japonicum on Hair Growth
January 2017
in “
생약학회지
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TLDR Crinum asiaticum extract and norgalanthamine may promote hair growth by blocking an enzyme linked to hair loss and a pathway that stops hair growth.
The study from 6 years ago investigated the mechanisms of Crinum asiaticum var. japonicum and its active component, norgalanthamine, on hair growth. The extract of C. asiaticum var. japonicum was found to inhibit 5α-reductase activity by 16%, which is significant as this enzyme converts testosterone to dihydrotestosterone (DHT), a main cause of androgenetic alopecia. However, the extract did not function as an opener of the KATP channel. Norgalanthamine was found to inhibit the transforming growth factor-β (TGF-β) signal pathway, which is essential in the regression induction of hair growth. It specifically inhibited the phosphorylation of Smad2/3 on TGF-β1-induced canonical pathway in human keratinocyte HaCaT cells. These results suggested that the C. asiaticum var. japonicum extract and norgalanthamine had the potential to influence hair growth through the inhibition of 5α-reductase activity and TGF-β1-induced canonical pathway.