Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease
February 2016
in “
Cell Transplantation
”
next-generation sequencing RNA-seq interfollicular keratinocytes hair follicles dermal fibroblasts dermal papilla cells C57BL/6 murine skin differentially expressed genes gene ontology quiescent cell cycle signaling pathways hair follicle-related diseases genetically targeted therapies bioengineering applications NGS RNA sequencing IFKs HFs DFs DPCs mouse skin DEGs gene function cell cycle signaling hair diseases targeted therapies bioengineering
Studysummary In this study, researchers found that hair follicles and dermal fibroblasts, including dermal papilla cells, supported sustained hair growth in transplanted murine models, with RNA-seq analysis revealing active signaling pathways and gene expression patterns.
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