Potential Roles of FGF5 as a Candidate Therapeutic Target in Prostate Cancer

January 2023 in “ PubMed ”

Mary M. Stangis, Avan N Colah, Dalton McLean, Richard B. Halberg, Lara S. Collier, William A. Ricke

Fibroblast growth factor 5 FGF5 Hedgehog signaling pathway prostate cancer benign prostatic hyperplasia oncogenic driver stemness metastatic potential tumor proliferation

Studysummary This review discusses the potential role of FGF5 as a therapeutic target in prostate cancer and other conditions but reports no new results, highlighting a need for further research on FGF5 inhibitors.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice

9 citations , July 2021 in “Frontiers in Pharmacology”

This study found that intradermal injection of cholesterol-modified siRNA targeting FGF5 or FGF18, or topical application of FGF18-targeted siRNA, effectively influenced hair follicle cycles in mice, suggesting potential benefits for alopecia management.

research The Clinical Applications of Five-Alpha Reductase Inhibitors

2 citations , April 2021 in “Canadian Journal of Urology”

This review summarizes existing studies on 5-alpha reductase inhibitors, noting their effectiveness in reducing prostate volume and cancer risk but highlighting an increased risk of higher grade prostate cancer.

research Specific Inhibition of FGF5-Induced Cell Proliferation by RNA Aptamers

15 citations , February 2021 in “Scientific Reports”

This study found that novel RNA aptamers specifically inhibited FGF5-induced cell proliferation, suggesting their potential as candidates for treating FGF5-related diseases or hair disorders.

research Crosstalk Between Androgen and Wnt/β-Catenin Leads to Changes in Wool Density in FGF5-Knockout Sheep

23 citations , May 2020 in “Cell Death and Disease”

This study generated FGF5-knockout Dorper sheep using the CRISPR/Cas9 system, resulting in significantly increased fine-wool and active hair-follicle density, and explored downstream signaling pathways for potential applications in androgen alopecia treatment.

research Eclipta Prostrata Promotes the Induction of Anagen, Sustains the Anagen Phase Through Regulation of FGF-7 and FGF-5

7 citations , January 2019 in “Pharmaceutical Biology”

This study suggests that Eclipta prostrata may promote hair growth in mice and human dermal papilla cells through regulating FGF-7 and mTOR signaling.

research Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells

105 citations , October 2017 in “Stem cells”

This review discusses Wnt signaling pathways in skin development and stem cell regulation, highlighting potential interactions with other pathways but reports no new findings.

research Androgens and Androgen Receptor Action in Skin and Hair Follicles

100 citations , September 2017 in “Molecular and Cellular Endocrinology”

This review discusses the molecular mechanisms of androgens and androgen receptors in skin disorders, particularly androgenetic alopecia, and reports no new clinical results; it highlights potential areas for future treatment development.

research CRISPR/Cas9-Mediated Loss of FGF5 Function Increases Wool Staple Length in Sheep

47 citations , June 2017 in “The FEBS journal”

This study found that CRISPR/Cas9-induced loss-of-function mutations in the FGF5 gene significantly increased wool length and yield in genetically modified Chinese Merino sheep compared to wild-type controls.

Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

research Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

27 citations , February 2017 in “Clinical, Cosmetic and Investigational Dermatology”

In this study, a topical formulation with compounds from the monoterpenoid family significantly improved hair growth indicators like anagen:telogen ratio, hair fall, and visual hair density in men and women with pattern hair loss.

Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

research Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

47 citations , October 2016 in “Molecular and Cellular Endocrinology”

This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.

research Molecular Cloning, Characterization, and Expression of Sheep FGF5 Gene

11 citations , October 2014 in “Gene”

In this study, researchers characterized the FGF5 gene in Chinese Merino sheep, identified a new mRNA splicing variant, FGF5S, and noted its restricted expression in the brain, spleen, and skin.

research FGF5 Is a Crucial Regulator of Hair Length in Humans

136 citations , July 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

This study identified mutations in the FGF5 gene as a cause of extreme eyelash growth in Pakistani families, highlighting a potential target for regulating eyelash growth.

Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

95 citations , January 2012 in “British Journal of Dermatology”

This study found that androgens inhibit hair follicle stem cell differentiation by disrupting the Wnt signalling pathway in dermal papilla cells, but Wnt activation can restore differentiation.

research Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats

75 citations , September 2007 in “Journal of Heredity”

This study found that mutations in the FGF5 gene are the primary genetic factor causing long hair in domestic cats through an autosomal recessive mechanism.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research The Long And The Short Of It: Evidence That FGF5 Is A Major Determinant Of Canine Hair-Itability

73 citations , June 2006 in “Animal genetics”

This study found that a missense mutation in the FGF5 gene is associated with hair-length differences among various dog breeds.

research Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression

69 citations , May 1997 in “Veterinary Pathology”

This study found that the angora mouse mutation prolongs the anagen phase, resulting in excessively long hair and follicular abnormalities, without involving circulating hair cycle factors.