Exosomes and Hair Restoration
May 2023
in “Advances in Cosmetic Surgery”
TLDR Exosomes, tiny cell-released particles, may help hair growth, but their exact role is unclear, they're not FDA-approved, and their unregulated use can cause side effects.
Exosomes are small vesicles released by cells that contain proteins, mRNAs, and microRNAs. They have been found to play a role in hair growth by delivering molecular signals to hair follicle components and interacting with molecules involved in hair growth regulation. However, the specific effects of exosomes on hair regeneration are not fully understood and may vary depending on their source. Currently, there are no FDA-approved exosome therapies for hair growth and regeneration, and caution is advised due to reports of adverse effects from unregulated use. More controlled human clinical research is needed to determine the effectiveness and safety of exosomes for hair restoration.
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Cited in this study
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research Photobiomodulation promotes hair regeneration in injured skin by enhancing migration and exosome secretion of dermal papilla cells
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research Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation
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research Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling
Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
research Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair‐inductive capacity of cultured dermal papilla spheres
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research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth
research Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons
Understanding hair follicle biology and stem cell control could lead to new hair loss treatments.
research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata
research Regulation of hair follicle development by exosomes derived from dermal papilla cells
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research Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss
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