Connarus semidecandrus Jack Exerts Anti-Alopecia Effects by Targeting 5α-Reductase Activity and an Intrinsic Apoptotic Pathway

    June 2022 in “Molecules
    TLDR Connarus semidecandrus Jack extract promotes hair growth and thickness, reduces prostate cancer cell growth, and could potentially be used as a treatment for hair loss.
    The study investigated the anti-alopecia effects of Connarus semidecandrus Jack ethanol extract (Cs-EE), a plant traditionally used for fever relief. The research showed that Cs-EE promoted hair growth and thickness in a testosterone-induced androgenic alopecia mouse model by reducing 5α-reductase activity and androgen receptor protein levels, and inhibiting programmed cell death. Cs-EE also suppressed prostate cancer cell proliferation and stimulated human hair-follicle dermal papilla cell proliferation. The study concludes that Cs-EE could potentially be used as a treatment for androgenic alopecia by regulating the androgenic or apoptotic axis.
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