Connarus semidecandrus Jack Exerts Anti-Alopecia Effects by Targeting 5α-Reductase Activity and an Intrinsic Apoptotic Pathway
June 2022
in “Molecules”
TLDR
Connarus semidecandrus Jack extract promotes hair growth and thickness, reduces prostate cancer cell growth, and could potentially be used as a treatment for hair loss.
The study investigated the anti-alopecia effects of Connarus semidecandrus Jack ethanol extract (Cs-EE), a plant traditionally used for fever relief. The research showed that Cs-EE promoted hair growth and thickness in a testosterone-induced androgenic alopecia mouse model by reducing 5α-reductase activity and androgen receptor protein levels, and inhibiting programmed cell death. Cs-EE also suppressed prostate cancer cell proliferation and stimulated human hair-follicle dermal papilla cell proliferation. The study concludes that Cs-EE could potentially be used as a treatment for androgenic alopecia by regulating the androgenic or apoptotic axis.
View this study on mdpi.com →
Cited in this study
research Effects of Acanthus ebracteatus Vahl. extract and verbascoside on human dermal papilla and murine macrophage
Acanthus ebracteatus Vahl. extract and verbascoside may help prevent hair loss and promote hair growth due to their anti-inflammatory properties and ability to protect against cell death.
research Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells
Polygonum multiflorum extract helps hair grow longer and fights the effects of hormones that cause hair loss.
research Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study
research Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia
Flutamide, delivered by solid lipid nanoparticles, could potentially treat hair loss.
research Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract ofQuercus acutissimaCortex
research Emerging treatments in alopecia
New alopecia treatments aim for better results and fewer side effects.
research Minoxidil may suppress androgen receptor-related functions
Minoxidil can reduce functions related to androgen receptors.
research Clinical biochemistry of dihydrotestosterone
Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
research Characteristics of Androgenetic Alopecia in Asian
Asian hair loss differs from Europeans; consider individual needs and psychological well-being for treatment.
research Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss
Finasteride for hair loss can cause long-lasting sexual side effects like low libido and erectile dysfunction.
research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia
Oral finasteride works better than topical minoxidil for hair growth, both are safe.
research Treatment of hyperandrogenic alopecia in women
research Molecular mechanisms of androgenetic alopecia
AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.