Chitin Derivative-Based Detachable Microneedles for Effective Treatment of Androgenic Alopecia

April 2026 in “ Advanced Healthcare Materials ”

Jiaxue Zhang, Jiaxue Zhang, Yijia Zhang, Ying Yang, Wenhui Bai, Zhiqi Wang, Chen Yang, Peipei Zhang, Qin Li, Lei Zhang, Lei Zhang, Jia Ma

androgenic alopecia detachable microneedles TEMPO-oxidized chitin derivatives C57BL/6j AGA models hair regrowth minoxidil lysosomal hydrolases membrane proteins autophagy hair follicles dermal toxicity visceral toxicity chitin derivatives AGA CD MNs Rogaine

Studysummary In this study, researchers tested detachable microneedles with chitin derivatives in a mouse model of androgenic alopecia, finding them to induce greater hair regrowth than 5% minoxidil, while also positing these materials as safe and cost-effective alternatives for hair loss treatment.

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