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Glossary Transmembrane Protein

spans the entire cell membrane, facilitating transport and signaling

A transmembrane protein, also known as an integral membrane protein, is a type of protein that spans the entire lipid bilayer of a cell membrane. These proteins play crucial roles in various cellular processes, such as transporting molecules across the membrane, acting as receptors for signaling molecules, and maintaining the cell's structural integrity.

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research Advances in structure-based drug design targeting membrane protein markers in prostate cancer

5 citations , August 2024 in “Drug Discovery Today”

This review examines advances in computer-aided drug design for targeting membrane proteins in prostate cancer but reports no new clinical results; it emphasizes the potential of structural insights and compound screening for therapeutic development.

research Phospholipase A2 Is Required for PIN-FORMED Protein Trafficking to the Plasma Membrane in theArabidopsisRoot

84 citations , June 2010 in “The Plant Cell”

In this study, disruptions in phospholipase A2 activity in Arabidopsis thaliana significantly impaired the plasma membrane localization of PIN proteins, affecting auxin transport and root development.

research Remodelling of cytoskeleton and plasma membrane proteins contributes to drought sensitivity of Arabidopsisrhd2mutant

July 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that Arabidopsis thaliana mutants with altered AtRBOHC/RHD2 enzyme function showed abnormal protein regulation linked to increased drought sensitivity due to disrupted plasma membrane protein balance and cytoskeleton changes, as revealed through proteomic analysis and advanced microscopy.

research Expression of MAEG, a novel basement membrane protein, in mouse hair follicle morphogenesis

41 citations , February 2005 in “Experimental Cell Research”

This study suggests that the MAEG protein may facilitate epithelial–mesenchymal interactions during hair follicle development by binding to RGD-binding integrins like α8β1.

research Expression of Basement Membrane Proteins and Interstitial Collagens in Dermal Papillae of Human Hair Follicles

85 citations , January 1991 in “Journal of Investigative Dermatology”

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community The end of balding: We may have just found the secret to hair regrowth

in Technology 680 upvotes 1 year ago

MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.

community Minoxidil’s mechanism of action on blood pressure as a potassium channel opening molecule

in Research 83 upvotes 7 months ago

Minoxidil works by opening potassium channels, leading to reduced blood pressure and potential side effects like reflex tachycardia. It is used for hair growth and affects blood pressure at high doses.

community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

23 upvotes 1 year ago

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

community My Fluridil/Eucapil 2% experience 30 days.

4 upvotes 5 years ago

The user experienced side effects like fatigue and aches after using Eucapil 2% for hair loss, suspecting it went systemic. Other users debated whether Eucapil can cause such effects, with some suggesting it might affect testosterone levels.

community 2 months apart, Are these bumps follicles?

9 upvotes 1 year ago

The user is using a mix of supplements, including Minoxidil, to address androgenetic alopecia and is concerned about zinc dosage potentially causing issues. They plan to discuss their treatment and supplement regimen with a dermatologist.

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