Cellular Dynamics in the Niche of Infrequently Dividing Hair Follicle Stem Cells in the Mouse

    October 2010 in “ eCommons (Cornell University) ”
    Ying Zhang
    Studysummary This study found that mouse hair follicle stem cells use symmetric cell division for maintenance and fate determination, and identified Gata6 as a crucial factor for their differentiation.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ecommons.cornell.edu →
    Discuss this study in the Community →

    Research cited in this study 15

    1. Coexistence of Quiescent and Active Adult Stem Cells in Mammals Science · 2010
    2. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    3. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    4. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    5. Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America · 2005
    6. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    7. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    8. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    9. Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment Development · 2003
    10. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    11. Genetic Ablation of the CDP/Cux Protein C Terminus Results in Hair Cycle Defects and Reduced Male Fertility Molecular and cellular biology · 2002
    12. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    13. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000
    14. Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis Nature · 2000
    15. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000

    Related research 2

    1. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021
    2. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007