Alopecias

January 2011 in “ Humana Press eBooks ”

Diane M. Hoss, Michael J. Murphy

alopecia androgens androgen receptor gene male pattern hair loss female pattern hair loss finasteride androgen receptor gene polymorphism Propecia

TLDR The document discussed hair loss causes and treatments but didn't give a final summary.

The document from 2011 was a collection of references on alopecia, discussing various aspects of the condition such as histopathology, immune response, cell cycle control, apoptosis, and genetic factors. It emphasized the role of androgens and the androgen receptor gene in male and female pattern hair loss. The document also discussed the effectiveness of finasteride, a hair loss treatment, in relation to androgen receptor gene polymorphism. However, it did not provide a comprehensive review or conclusion on these topics.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

28 / 28 results

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations, June 2010 in “Nature”

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

Peripheral Blood Gene Expression in Alopecia Areata Reveals Molecular Pathways Distinguishing Heritability, Disease, and Severity

research Peripheral Blood Gene Expression in Alopecia Areata Reveals Molecular Pathways Distinguishing Heritability, Disease, and Severity

20 citations, June 2010 in “Genes and Immunity”

Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.

research Alopecia Areata Update

391 citations, January 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research Histopathology of Alopecia: A Clinicopathological Approach to Diagnosis

170 citations, December 2009 in “Histopathology”

The conclusion is that accurate diagnosis of different types of hair loss requires good teamwork between skin doctors and lab experts.

research Evaluation of Androgen Receptor Gene as a Candidate Gene in Female Androgenetic Alopecia

23 citations, May 2009 in “International Journal of Dermatology”

AR gene not major factor in female hair loss; different from male hair loss.

research Androgens and Hair Growth

209 citations, September 2008 in “Dermatologic Therapy”

Androgens can both increase and decrease hair growth in different parts of the body.

research EDA2R Is Associated With Androgenetic Alopecia

82 citations, September 2008 in “Journal of Investigative Dermatology”

EDA2R gene linked to hair loss.

research Secondary Cicatricial and Other Permanent Alopecias

20 citations, July 2008 in “Dermatologic Therapy”

The document says that treating the root cause of hair follicle damage is crucial to prevent permanent hair loss, and treatment options vary.

research Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26

62 citations, March 2008 in “American Journal of Human Genetics”

Hair loss gene found on chromosome 3q26.

Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

research Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

60 citations, January 2007 in “Human Genetics”

AR polyglycine repeat doesn't cause baldness.

research Finasteride Treatment of Female Pattern Hair Loss

108 citations, March 2006 in “Archives of Dermatology”

Finasteride with oral contraceptive helps improve hair loss in premenopausal women.

research Effectiveness of Finasteride on Patients with Male Pattern Baldness Who Have Different Androgen Receptor Gene Polymorphism

23 citations, December 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Finasteride works better for baldness in people with shorter gene repeats.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations, July 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

155 citations, December 2003 in “British Journal of Dermatology”

Hair loss increases with age; alcohol raises risk, more female partners lowers it.

The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

research The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

49 citations, August 2003 in “Journal of The American Academy of Dermatology”

Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.

research Hair Loss in Women with Hyperandrogenism: Four Cases Responding to Finasteride

92 citations, October 2002 in “Journal of The American Academy of Dermatology”

Finasteride improves hair loss in women with hyperandrogenism.

research Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans

114 citations, August 2002 in “Journal of Investigative Dermatology”

Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.

research Female Pattern Hair Loss

86 citations, July 2002 in “Clinical and Experimental Dermatology”

FPHL is a common, age-related, genetic hair loss with unclear causes and limited treatment options.

research Female Pattern Hair Loss

226 citations, September 2001 in “Journal of The American Academy of Dermatology”

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

research Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia

239 citations, November 2000 in “Journal of The American Academy of Dermatology”

Finasteride doesn't effectively treat hair loss in postmenopausal women.

research The Hair Follicle: A Paradoxical Androgen Target Organ

66 citations, January 2000 in “Hormone Research in Paediatrics”

Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.

research Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp

100 citations, September 1999 in “British Journal of Dermatology”

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations, October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

research Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne

186 citations, July 1998 in “Journal of Cutaneous Medicine and Surgery”

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

227 citations, January 1998 in “Journal of Endocrinology”

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations, September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia

143 citations, October 1996 in “Dermatologic Clinics”

Too much androgen can cause hair loss; finasteride may help.

research Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp

124 citations, April 1992 in “Journal of Endocrinology/Journal of endocrinology”

Beard hair follicles have more androgen receptors than non-balding scalp hair follicles.

Related Community Posts Join

6 / 1000+ results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 11 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community A Different Take on Curing MBP

16 upvotes 6 years ago

Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

community 6 months on dutast and minoxodil, hair growing like weeds now!

in Progress Pictures 607 upvotes 3 weeks ago

A woman experienced significant hair regrowth after six months of using dutasteride and minoxidil, despite initial hair loss due to androgenetic alopecia. She reported minimal side effects and highlighted the effectiveness of these treatments for women, despite doctors' hesitancy to prescribe them.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 1 year ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 160 upvotes 1 year ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

Similar Research

5 / 1000+ results

research The Endocrinology of Baldness

19 citations, April 2014 in “Hormones”

Hormones and genetics play key roles in male and female baldness, which can affect mental health and may be linked to other health issues.

research An Overview of Female Pattern Hair Loss

2 citations, June 2011 in “Expert Review of Dermatology”

Female pattern hair loss involves thinning hair on crown and frontal scalp, diagnosed by hair ratio, and treated with minoxidil, antiandrogens, or hair transplantation.

research Androgens and Hair: A Biological Paradox

11 citations, January 2001 in “Cambridge University Press eBooks”

Androgens can cause hair growth in some areas but hair loss on the scalp.

research Androgenetic Alopecia: Update on Etiology

1 citations, March 2021 in “Dermatological reviews”

AGA, a common hair loss, is caused by genetics, hormones, age, and environmental factors.

research Experimental and Early Investigational Drugs for Androgenetic Alopecia

11 citations, July 2017 in “Expert Opinion on Investigational Drugs”

New hair loss treatments may include topical medications, injections, and improved transplant methods.