Alopecias

January 2011 in “ Humana Press eBooks ”

Diane M. Hoss, Michael J. Murphy

alopecia androgens androgen receptor gene male pattern hair loss female pattern hair loss finasteride androgen receptor gene polymorphism Propecia

TLDR The document discussed hair loss causes and treatments but didn't give a final summary.

The document from 2011 was a collection of references on alopecia, discussing various aspects of the condition such as histopathology, immune response, cell cycle control, apoptosis, and genetic factors. It emphasized the role of androgens and the androgen receptor gene in male and female pattern hair loss. The document also discussed the effectiveness of finasteride, a hair loss treatment, in relation to androgen receptor gene polymorphism. However, it did not provide a comprehensive review or conclusion on these topics.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

35 / 35 results

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

Peripheral Blood Gene Expression in Alopecia Areata Reveals Molecular Pathways Distinguishing Heritability, Disease, and Severity

research Peripheral Blood Gene Expression in Alopecia Areata Reveals Molecular Pathways Distinguishing Heritability, Disease, and Severity

20 citations , June 2010 in “Genes and Immunity”

Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research Histopathology of Alopecia: A Clinicopathological Approach to Diagnosis

170 citations , December 2009 in “Histopathology”

The conclusion is that accurate diagnosis of different types of hair loss requires good teamwork between skin doctors and lab experts.

research MicroRNAs Take Part in Pathophysiology and Pathogenesis of Male Pattern Baldness

21 citations , October 2009 in “Molecular Biology Reports”

research Evaluation of Androgen Receptor Gene as a Candidate Gene in Female Androgenetic Alopecia

23 citations , May 2009 in “International Journal of Dermatology”

AR gene not major factor in female hair loss; different from male hair loss.

research Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11

140 citations , October 2008 in “Nature Genetics”

research Androgens and Hair Growth

209 citations , September 2008 in “Dermatologic Therapy”

Androgens can both increase and decrease hair growth in different parts of the body.

research Secondary Cicatricial and Other Permanent Alopecias

20 citations , July 2008 in “Dermatologic Therapy”

The document says that treating the root cause of hair follicle damage is crucial to prevent permanent hair loss, and treatment options vary.

research EDA2R Is Associated With Androgenetic Alopecia

82 citations , April 2008 in “Journal of Investigative Dermatology”

EDA2R gene linked to hair loss.

research Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26

62 citations , March 2008 in “American Journal of Human Genetics”

Hair loss gene found on chromosome 3q26.

Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

research Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

60 citations , January 2007 in “Human Genetics”

AR polyglycine repeat doesn't cause baldness.

research Finasteride Treatment of Female Pattern Hair Loss

108 citations , March 2006 in “Archives of Dermatology”

Finasteride with oral contraceptive helps improve hair loss in premenopausal women.

research Effectiveness of Finasteride on Patients with Male Pattern Baldness Who Have Different Androgen Receptor Gene Polymorphism

23 citations , November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Finasteride works better for baldness in people with shorter gene repeats.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Genetic Basis of Male Pattern Baldness

191 citations , December 2003 in “Journal of Investigative Dermatology”

Male pattern baldness is largely genetic, linked to the androgen receptor gene, and may relate to certain health issues.

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

155 citations , December 2003 in “British Journal of Dermatology”

Hair loss increases with age; alcohol raises risk, more female partners lowers it.

The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

research The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

49 citations , August 2003 in “Journal of The American Academy of Dermatology”

Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.

research Hair Loss in Women with Hyperandrogenism: Four Cases Responding to Finasteride

92 citations , October 2002 in “Journal of The American Academy of Dermatology”

Finasteride improves hair loss in women with hyperandrogenism.

research Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans

114 citations , August 2002 in “Journal of Investigative Dermatology”

Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.

research Female Pattern Hair Loss

86 citations , July 2002 in “Clinical and Experimental Dermatology”

FPHL is a common, age-related, genetic hair loss with unclear causes and limited treatment options.

research Female Pattern Hair Loss

226 citations , September 2001 in “Journal of The American Academy of Dermatology”

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

299 citations , March 2001 in “Journal of Investigative Dermatology”

Male pattern baldness is linked to specific genetic variations in the androgen receptor gene.

research Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia

239 citations , November 2000 in “Journal of The American Academy of Dermatology”

Finasteride doesn't effectively treat hair loss in postmenopausal women.

research The Hair Follicle: A Paradoxical Androgen Target Organ

66 citations , January 2000 in “Hormone Research in Paediatrics”

Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.

research Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp

100 citations , September 1999 in “British Journal of Dermatology”

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

research Diffuse Female Hair Loss: Are Androgens Necessary?

110 citations , September 1999 in “British Journal of Dermatology”

Female hair loss can occur without androgens.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

research Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne

186 citations , July 1998 in “Journal of Cutaneous Medicine and Surgery”

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

research Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes

169 citations , June 1998 in “Journal of Investigative Dermatology”

Male pattern baldness is likely caused by multiple genes, not just 5α-reductase genes.

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

227 citations , January 1998 in “Journal of Endocrinology”

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia

143 citations , October 1996 in “Dermatologic Clinics”

Too much androgen can cause hair loss; finasteride may help.

research Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp

124 citations , April 1992 in “Journal of Endocrinology/Journal of endocrinology”

Beard hair follicles have more androgen receptors than non-balding scalp hair follicles.

research The Inheritance Of Common Baldness: To Be Or Not To Be?

203 citations , November 1984 in “Journal of the American Academy of Dermatology”

Common baldness is likely inherited through multiple genes, not just one.

Similar Research

5 / 1000+ results

research The Endocrinology of Baldness

19 citations , April 2014 in “Hormones”

Hormones and genetics play key roles in male and female baldness, which can affect mental health and may be linked to other health issues.

The Genetic Landscape of Androgenetic Alopecia: Current Knowledge and Future Perspectives