Dissecting Hair Breakage in Alopecia Areata: The Central Role of Dysregulated Cysteine Homeostasis

    May 2024 in “ Amino Acids ”
    Wen Xu, Bo Xie, Dongfan Wei, Xiuzu Song
    Studysummary This review identifies cysteine's central role in hair growth and its potential impact on Alopecia Areata's pathogenesis, suggesting examination of cysteine metabolism might clarify the disease's underlying mechanisms and lead to new treatments.
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    Research cited in this study 24

    1. Baricitinib for the Treatment of Alopecia Areata Drugs · 2023
    2. Effects of Allium Hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells Plants · 2023
    3. Novel Potential Therapeutic Targets of Alopecia Areata Frontiers in Immunology · 2023
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    9. Trichothiodystrophy Hair Shafts Display Distinct Ultrastructural Features Experimental dermatology · 2022
    10. The Susceptibility of Disulfide Bonds to Modification in Keratin Fibers Undergoing Tensile Stress Biophysical Journal · 2022
    11. Homozygous Whole Body Cbs Knockout in Adult Mice Features Minimal Pathology During Aging Despite Severe Homocysteinemia ˜The œFASEB journal · 2022
    12. Whole Exome Sequencing in Alopecia Areata Identifies Rare Variants in KRT82 Nature communications · 2022
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    18. Comorbidities in Alopecia Areata: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2018
    19. Trichoscopy of Alopecia Areata: An Update The Journal of Dermatology · 2018
    20. Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria Molecular therapy · 2017
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    22. Ten Pearls Every Dermatologist Should Know About the Appropriate Use of Relaxers Journal of cosmetic dermatology · 2016
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    24. Influence of FHIT on Benzo[a]pyrene-Induced Tumors and Alopecia in Mice: Chemoprevention by Budesonide and N-Acetylcysteine Proceedings of the National Academy of Sciences of the United States of America · 2006

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