Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin

    January 2011 in “ Journal of Biological Chemistry ”
    Christoph J. Binder, Yoshitaka Taketomi, Yuki Isogai … Makoto Murakami
    Studysummary This study found that overexpression of sPLA2-X in mice was associated with alopecia and hair follicle abnormalities, highlighting its potential role in hair follicle homeostasis.
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    Research cited in this study 17

    1. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    2. Impaired Skin And Hair Follicle Development In Runx2 Deficient Mice Developmental Biology · 2008
    3. Phospholipase C-δ1 Is an Essential Molecule Downstream of Foxn1, the Gene Responsible for the Nude Mutation, in Normal Hair Development The FASEB Journal · 2007
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    5. Scratching the Surface of Skin Development Nature · 2007
    6. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    7. The Hair Cycle Journal of Cell Science · 2006
    8. Spink5-Deficient Mice Mimic Netherton Syndrome Through Degradation of Desmoglein 1 by Epidermal Protease Hyperactivity Nature Genetics · 2004
    9. Epidermal Differentiation: The Role of Proteases and Their Inhibitors European Journal of Cell Biology · 2004
    10. Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia Upon Cyclooxygenase-2 Overexpression Journal of Investigative Dermatology · 2003
    11. Phospholipase Cδ1 Is Required for Skin Stem Cell Lineage Commitment The EMBO Journal · 2003
    12. Hair-Cycle-Dependent Expression of Parathyroid Hormone-Related Protein and Its Type I Receptor: Evidence for Regulation at the Anagen to Catagen Transition ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2003
    13. Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in Nackt Mice, a Cathepsin L-Deficient Mutation American Journal Of Pathology · 2002
    14. Cyclooxygenase-2 Overexpression in the Skin of Transgenic Mice Results in Suppression of Tumor Development PubMed · 2002
    15. Abnormal Differentiation of Epidermis in Transgenic Mice Constitutively Expressing Cyclooxygenase-2 in Skin Proceedings of the National Academy of Sciences · 2001
    16. Manipulation of Outer Root Sheath Cell Survival Perturbs the Hair-Growth Cycle The EMBO Journal · 1999
    17. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997

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