TLR9 Activation in Large Wound Induces Tissue Repair and Hair Follicle Regeneration via γδT Cells

    August 2024 in “ Cell Death and Disease ”
    Xinhui Li, Tiantian An, Yang Yang … Chen Hu
    Studysummary This study found that toll-like receptor 9 plays a previously unrecognized role in sensing skin injury and influencing tissue repair and regeneration in adult mice by modulating γδT cell migration.
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    Research cited in this study 19

    1. Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration Nature Communications · 2023
    2. Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism Science Advances · 2023
    3. Neutrophil Extracellular Traps Impair Regeneration Journal of Cellular and Molecular Medicine · 2021
    4. The Global Regulatory Logic Of Organ Regeneration: Circuitry Lessons From Skin And Its Appendages Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2021
    5. Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing Science Advances · 2021
    6. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    7. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing Cell stem cell · 2020
    8. Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3 Nature Communications · 2019
    9. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    10. Msx2 Supports Epidermal Competency During Wound-Induced Hair Follicle Neogenesis Journal of Investigative Dermatology · 2018
    11. Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth Journal of Investigative Dermatology · 2017
    12. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    13. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    14. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    15. Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis Regeneration · 2015
    16. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    17. KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin Development · 2009
    18. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    19. Growth Factor and Growth Factor Receptor Localization in the Hair Follicle Bulge and Associated Tissue in Human Fetus Journal of Investigative Dermatology · 1996

    Related research 10

    1. Wound-Induced Hair Follicle Neogenesis as a Promising Approach for Hair Regeneration Molecules and Cells · 2023
    2. May the Best Wound WIHN: The Hallmarks of Wound-Induced Hair Neogenesis Current Opinion in Genetics & Development · 2021
    3. Wound-Induced Hair Neogenesis: A Novel Paradigm for Studying Regeneration and Aging Frontiers in Cell and Developmental Biology · 2020
    4. Wound-Induced Hair Follicle Neogenesis: A New Perspective on Hair Follicle Regeneration in Adult Mammals PubMed · 2020
    5. Hair Follicle Neogenesis in Adult Skin The Molecular Biology Society of Japan · 2018
    6. Activin A-Induced Signaling Controls Hair Follicle Neogenesis Experimental Dermatology · 2016
    7. Inducing Hair Follicle Organogenesis With Defined Environmental Protein Factors Journal of Dermatological Science · 2016
    8. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    9. Do We Need Hair Follicle Stem Cells and Hair Follicle Neogenesis to Cure Common Hair Loss Disorders? Hair transplant forum international · 2008
    10. New Hair From Healing Wounds Nature · 2007