A Proteoglycan-Based Topical Treatment for Hair Greying: In Vitro Antioxidant and Pro-Melanogenic Effects

    January 2026 in “ Frontiers in Medicine ”
    David Vega Díez, Eva María Arias, Núria Floriach, Estela Bravo
    Studysummary In this study, PP-PTKL exhibited antioxidant, anti-inflammatory, and pro-melanogenic effects in laboratory settings, suggesting its potential role in preventing or treating hair greying. Further animal and human studies are needed to verify these findings.
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    Research cited in this study 17

    1. Gray Hair: From Prevention to Treatment Clinical Cosmetic and Investigational Dermatology · 2025
    2. Hair Graying: Mechanisms, Prevention, And Innovative Treatment Strategies – Literature Review Quality in Sport · 2024
    3. Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity International Journal of Molecular Sciences · 2023
    4. The Suppression Effects of Fat Mass and Obesity Associated Gene on Hair Follicle-Derived Neural Crest Stem Cells Differentiating into Melanocytes by N6-Methyladenosine Modifying Microphthalmia-Associated Transcription Factor International Journal of Stem Cells · 2023
    5. Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms Behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin with Marilex in Pattern Hair Loss and Telogen Effluvium Dermatology Research and Practice · 2020
    6. 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes Frontiers in cell and developmental biology · 2020
    7. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    8. Histopathology of Aging of the Hair Follicle Journal of Cutaneous Pathology · 2019
    9. Wnt/β-Catenin Signaling Pathway Activates Melanocyte Stem Cells In Vitro and In Vivo Journal of Dermatological Science · 2016
    10. Acute Stress-Induced Changes in Follicular Dermal Papilla Cells and Mobilization of Mast Cells: Implications for Hair Growth Annals of Dermatology · 2016
    11. Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors PLOS ONE · 2014
    12. Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress International Journal of Cosmetic Science · 2013
    13. Microarray Analysis of Androgenetic and Senescent Alopecia: Comparison of Gene Expression Shows Two Distinct Profiles Journal of Dermatological Science · 2013
    14. Characteristic Features of Ageing in Korean Women's Hair and Scalp British Journal of Dermatology · 2012
    15. Aging of the Hair Follicle Pigmentation System International journal of trichology · 2009
    16. Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage ˜The œFASEB journal · 2006
    17. Aging of Hair Journal of Cosmetic Dermatology · 2005