Exploring the Synergic Effects of a Plant and a Peptide on Hair Follicle Pigmentation

The study explored the synergistic effects of GreyverseTM (Gv), a synthetic peptide mimicking αMSH, and Paeonia Suffruticosa root bark extract (PS) on hair follicle pigmentation. In vitro and ex vivo experiments demonstrated that the combination of PS and Gv significantly increased melanin content and promoted melanogenesis in human hair follicles. This was evidenced by increased Gp100 expression, tyrosinase activity, and αMSH and TYRP expression. The findings suggested that the combinational treatment of PS and Gv could effectively promote hair pigmentation and potentially reverse hair greying, warranting further pre-clinical and clinical studies.