September 201725
Annurca apple procyanidin supplementation was found to increase hair growth, density and keratin content in a randomized trial. A marine-protein supplement for thinning hair was reported across five trials to increase hair growth and diameter while reducing shedding. A review of PRP in hair loss concluded it stimulates growth and prolongs anagen, though techniques remain unstandardized. Adipose stem-cell conditioned media was reported to promote hair growth in vitro and in mice. A review of alopecia and metabolic syndrome linked androgenetic alopecia with cardiovascular risk and proposed screening. Six migraine patients receiving transplants reported complete headache cessation after surgery. A review of chemotherapy-induced alopecia identified scalp cooling as the only cleared prevention, sparing about half of users a wig.
- Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial In a randomized trial, an Annurca apple procyanidin B2 supplement increased hair growth, density and keratin content within two months.
- A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention A review of chemotherapy-induced alopecia finds scalp cooling the only FDA-cleared prevention, letting roughly half of users avoid a wig.
- Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy In mice, boosting WNT signaling mobilized follicle progenitors and prevented radiation- and cyclophosphamide-induced hair loss.
- The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors A review finds adipose stem-cell conditioned media promotes hair growth in vitro, ex vivo and in mice.
- Growing evidence of the beneficial effects of a marine protein-based dietary supplement for treating hair loss A review of five randomized trials says a marine-protein supplement increased hair growth and diameter and reduced shedding in thinning hair.
- The promotion of hair regrowth by topical application of a Perilla frutescens extract through increased cell viability and antagonism of testosterone and dihydrotestosterone In testosterone-sensitive mice, a Perilla frutescens fraction and its compound rosmarinic acid promoted hair regrowth via anti-androgen activity.
- Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice In testosterone-treated mice, red ginseng oil and its components linoleic acid and beta-sitosterol restored hair growth via Wnt and Shh pathways.
- Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering A review claims PRP stimulates hair growth and prolongs anagen, but notes techniques lack standardization and procedures are poorly described.
- Alopecia and the metabolic syndrome A review links androgenetic alopecia with metabolic syndrome and cardiovascular risk, prompting calls to screen AGA patients for these factors.
- Efficacy of topical tofacitinib in promoting hair growth in non-scarring alopecia: possible mechanism via VEGF induction In mice, topical tofacitinib produced more and faster hair regrowth than minoxidil, with increased VEGF expression and more anagen follicles.
- Hair Transplantation in Migraine Headache Patients Six hair-transplant patients with long-standing migraine reported complete cessation of headaches after surgery, with pain scores falling to zero.
- Hydrogen peroxide (H2O2) suppresses hair growth through downregulation of β-catenin Hydrogen peroxide suppresses hair growth by downregulating beta-catenin.
- Effective use of ustekinumab in a patient with concomitant psoriasis, vitiligo, and alopecia areata In one patient with psoriasis, vitiligo and alopecia areata, ustekinumab was effective.
- NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types In mice, NF-kB signaling controls hair cycle transitions and hair shaft bending, with distinct roles across pelage hair follicle types.
- Central Centrifugal Cicatricial Alopecia: New Insights and a Call for Action A review outlines central centrifugal cicatricial alopecia causes and treatments, noting therapy remains challenging and genetics research is needed.
- Editorial: Application of Mesenchymal Stem Cells and Their Secretory Factors for Hair Regeneration an editorial on applying mesenchymal stem cells and their secretory factors for hair regeneration.
- Pigment epithelium‑derived factor short peptides facilitate full‑thickness cutaneous wound healing by promoting epithelial basal cell and hair follicle stem cell proliferation In mice, short PEDF peptides accelerated wound healing and stimulated hair follicle stem-cell proliferation.
- Hair Loss: Common Causes and Treatment. A review summarizes common hair-loss causes and treatments for family doctors, noting androgenetic alopecia is treated with minoxidil.
- Lack of efficacy of apremilast in 9 patients with severe alopecia areata Apremilast lacked efficacy in 9 patients with severe alopecia areata.
- Androgens and androgen receptor action in skin and hair follicles A review examines androgen receptor molecular mechanisms in skin and androgenetic alopecia, surveying pathways for possible future treatments.
- Secretory phospholipase A2-IIA overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing response Mice overexpressing sPLA2-IIA develop cyclic alopecia through abnormal hair shaft differentiation and exhaustion of hair follicle stem cells.
- [Monilethrix is a hereditary hair shaft disorder]. A family case series of monilethrix notes low-dose oral minoxidil shows promise in a prior case report.
- Clinical Description of Frontal Fibrosing Alopecia with Concomitant Lichen Planopilaris A small series describes frontal fibrosing alopecia with coexisting lichen planopilaris, with frequent eyelash and body-hair involvement.
- Complete Regrowth of Beard Hair with Ruxolitinib in an Alopecia Universalis Patient In one patient with alopecia universalis, oral ruxolitinib restored complete beard growth after four months.
- Generation of iPS-derived model cells for analyses of hair shaft differentiation Researchers built a stem-cell-derived cell line that reports hair-shaft differentiation, enabling drug screening.