December 201735
Low-level laser therapy beat sham devices in a meta-analysis, and a review of laser trials reported improvement in most studies. Low-dose oral minoxidil with spironolactone was reported to reduce shedding and loss severity in women with pattern hair loss. Microneedling combined with minoxidil or PRP was reported effective, though superiority over standard therapy was unproven. Serum androgens in men showed vertex balding linked to higher DHT than frontal balding, and hair density in women was lowest in the parietal scalp. Vitamin D in non-scarring alopecia was reported low in most studies, suggesting supplementation may help, and tofacitinib for severe alopecia areata showed benefit in long-term use.
- Systematic review of low-level laser therapy for adult androgenic alopecia A meta-analysis of randomized trials found low-level laser therapy beats sham devices for pattern hair loss and is safe for home use, but results need cautious interpretation.
- Low-level laser therapy for the treatment of androgenic alopecia: a review A review of 13 trials found low-level laser therapy improved pattern hair loss in most studies, alone or with minoxidil or finasteride.
- Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone In 100 women, once-daily oral minoxidil 0.25 mg plus spironolactone 25 mg reduced shedding and loss severity over 12 months; side effects were mild (8 women), with no hyperkalemia.
- Microneedling for the treatment of hair loss? A review finds microneedling shows promise for pattern hair loss mainly combined with minoxidil or PRP, but superiority over standard therapy is unproven.
- Tofacitinib for the Treatment of Severe Alopecia Areata in Adults and Adolescents A review reports long-term tofacitinib use shows promise for severe alopecia areata in adults and adolescents, based on open-label trials.
- Serum androgens and prostate-specific antigen levels in androgenetic alopecia: is there a difference between frontal and vertex baldness? In 88 men with pattern hair loss, vertex balding was linked to higher serum DHT than frontal balding; PSA did not reflect androgen activity.
- The Role of Vitamin D in Non-Scarring Alopecia A review found most studies show low vitamin D in alopecia areata, telogen effluvium and female pattern hair loss, suggesting supplementation may help.
- Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter In 471 women with pattern hair loss, the parietal scalp showed the lowest density, an extra affected area relevant to transplant donor-site choice.
- A hypothetical pathogenesis model for androgenic alopecia: clarifying the dihydrotestosterone paradox and rate-limiting recovery factors A hypothesis paper proposing scalp tension-driven inflammation and fibrosis, not DHT directly, miniaturize follicles in pattern hair loss.
- Evaluating the antioxidant effects of human hair protein extracts In lab cultures, protein extracts from human hair showed antioxidant activity and protected skin cells from oxidative damage.
- Novel therapies for alopecia areata: The era of rational drug development A review tracing how alopecia areata treatment evolved toward targeted, rationally developed drugs.
- Scaffold-Assisted Artificial Hair Implantation in a Rat Model In rats, polyethylene and ePTFE scaffolds carrying artificial hair healed well in over 94% of implants, with progressive hair loss over 24 weeks.
- Frontal Fibrosing Alopecia: A Retrospective Analysis of 72 Patients from a German Academic Center In 72 patients with frontal fibrosing alopecia, high-potency steroid plus pimecrolimus stabilized the hairline after 9-12 months in most.
- Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management A review of hair follicle immune privilege collapse in alopecia areata and drug strategies to restore it.
- An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata A review of how platelet-rich plasma and microneedling might treat alopecia areata, noting only small studies exist so far.
- Treatment of Alopecia Areata with Simvastatin/Ezetimibe A review suggests simvastatin/ezetimibe may help acute but not chronic alopecia areata, partly via JAK/STAT modulation.
- Emerging Unconventional Therapies for Alopecia Areata A review discusses antihistamines, cryotherapy, and low-dose naltrexone as emerging but little-studied alopecia areata therapies.
- Race and Alopecia Areata amongst US Women In two large US nurse cohorts, black and Hispanic women had higher odds of alopecia areata than white women.
- Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases A review of cytokine pathways in alopecia areata and how targeted drugs from other inflammatory skin diseases might apply.
- Alopecia Areata: The Clinical Situation An overview of off-label alopecia areata treatment choices by age and disease extent, plus evolving JAK inhibitor research.
- Immune Privilege Collapse and Alopecia Development: Is Stress a Factor A review examines how immune privilege collapse and neurogenic stress may drive autoimmune hair loss.
- Selective delivery of adapalene to the human hair follicle under finite dose conditions using polymeric micelle nanocarriers In human skin samples, polymeric micelle formulations delivered adapalene selectively into hair follicles better than commercial gels.
- A review of monochromatic light devices for the treatment of alopecia areata A review found the 308-nm excimer laser regrew hair in refractory scalp and beard alopecia areata, while evidence for LLLT and fractional lasers is limited.
- Correlation of vitamin D and vitamin D receptor expression in patients with alopecia areata: a clinical paradigm In 30 alopecia areata patients, vitamin D deficiency was common and correlated with severity; follicle vitamin D receptor expression was reduced.
- Evaluation of Hair Density in Different Ethnicities in a Healthy American Population Using Quantitative Trichoscopic Analysis Trichoscopy showed hair density differs significantly by ethnicity, with Caucasians highest and those of African descent lowest, in healthy Americans.
- Alopecia areata A continuing-education review of alopecia areata's epidemiology, evaluation, prognosis and pathogenesis.
- Alopecia areata A review of alopecia areata treatments covering conventional therapies and emerging JAK inhibitors, their efficacy, side effects and durability.
- Prognosis, treatment, and disease outcomes in frontal fibrosing alopecia: A retrospective review of 92 cases a retrospective review of prognosis, treatment and outcomes in 92 frontal fibrosing alopecia cases.
- Vitamin D deficiency in patients with alopecia areata: A systematic review and meta-analysis a systematic review and meta-analysis of vitamin D deficiency in alopecia areata patients.
- Bottom-up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration Nanogel-encapsulated dermal papilla spheroids restored hair-inductive potential and regenerated follicles in a lab model.
- Use of low-level laser therapy in treatment of the androgenic alopecia, the first systematic review A systematic review examining whether low-level laser therapy effectively treats androgenic alopecia.
- Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq In five patients, WNT7A, CASP7 and TNF genes were overexpressed at early stages of pattern hair loss, implicating inflammation and apoptosis.
- RF-Scalp Cooling a note on RF scalp cooling for chemotherapy-induced hair loss.
- An Asian traditional herbal complex containing Houttuynia cordata Thunb, Perilla frutescens Var. acuta and green tea stimulates hair growth in mice In mice, an oral herbal complex of Houttuynia cordata, Perilla and green tea dose-dependently increased hair regrowth and follicle size.
- [What is the value of low-energie lasers in the treatment of androgenetic alopecia ?] A German-language review of the evidence, mechanisms and rare adverse events of low-level laser therapy for androgenetic alopecia.