February 201721
Non-activated PRP injections were found to improve hair count and density versus placebo, with results varying by collection device. A topical botanical FGF5 inhibitor was shown to reduce hair fall and increase apparent density in a placebo-controlled trial. Plasma rich in growth factors injections were reported to increase hair density, diameter and terminal-to-vellus ratio in a pilot. A visual shedding scale showed women with pattern hair loss shed about three times more hair than unaffected women. UK Biobank genetic analysis identified over 250 loci for baldness and predicted severe hair loss.
- Hormonal therapy in female pattern hair loss A review of hormonal mechanisms and available hormonal and hormone-modifying therapies for female pattern hair loss.
- Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems In a small split-scalp study, non-activated PRP injections improved hair count and density versus placebo, and results differed markedly between PRP collection devices.
- Hair loss at injection sites of mesotherapy for alopecia Three patients with pattern hair loss developed inflammatory scarring hair loss at mesotherapy injection sites, suggesting this unproven treatment can paradoxically worsen hair loss.
- Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process In a randomized placebo-controlled trial, a topical botanical FGF5 inhibitor improved anagen-to-telogen ratio, reduced hair fall and increased apparent density over 112 days.
- Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells Human induced pluripotent stem cells were programmed into dermal papilla-like cells that generated hair-shaft-like fibres when grafted with keratinocytes.
- The Hair Shedding Visual Scale: A Quick Tool to Assess Hair Loss in Women A validated visual scale showed women with female pattern hair loss shed about three times more hair than unaffected women, enabling quick office assessment.
- The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study In a 19-patient pilot, five plasma rich in growth factors injections increased hair density, diameter and terminal-to-vellus ratio over one year.
- Genetic prediction of male pattern baldness A UK Biobank study of over 52,000 men identified 250+ genetic loci for baldness and predicted severe hair loss with AUC 0.82.
- Chemotherapy‐induced alopecia management: Clinical experience and practical advice A review proposing practical steps for estimating risk and managing chemotherapy-induced alopecia before, during and after treatment.
- Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss White wax and its policosanol extract reduced testosterone-induced hair loss in mice, inhibiting 5-alpha reductase and outperforming topical finasteride in this model.
- Facial Feminization Surgery: Simultaneous Hair Transplant during Forehead Reconstruction Sixty-five transgender patients underwent forehead reconstruction with simultaneous hairline hair transplant in a single facial feminization operation.
- Basement Membrane Matrix Promotes the Efficiency of Hair Follicle Reconstruction In Vivo and Is a Cell Delivery Vehicle for Follicle Regeneration A basement membrane matrix shortened time to hair formation and increased new hairs in mouse follicle reconstruction grafts.
- Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells Icariin, a flavonoid from Epimedium, promoted mouse hair follicle growth by increasing IGF-1 expression in dermal papilla cells.
- Updates in the understanding and treatments of skin & hair disorders in women of color A review of acne, melasma and alopecia in women of color, covering traction alopecia and CCCA linked to hair care practices.
- What Ages Hair? An expert advisory board reviewed genetic, aging and environmental factors in hair loss and measures that may slow it.
- Hair camouflage: A comprehensive review A review describing wigs, extensions, concealing powders, scalp tattoos and transplants as options for camouflaging hair loss.
- Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice Geranium sibiricum extract promoted hair growth in mice and cultured dermal papilla cells, outperforming minoxidil in these models.
- Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration In mice, TPA accelerated hair follicle entry into anagen by activating stem cell proliferation and Akt and Wnt signaling.
- Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders In patient skin samples, Erdr1 protein was downregulated in hair loss disorders, especially alopecia areata, suggesting a possible biomarker.
- Changes of serum trace elements level in patients with alopecia areata: A meta‐analysis A meta-analysis of 764 subjects found alopecia areata patients have lower serum zinc and selenium than healthy controls.
- An Open-Label Evaluator Blinded Study of the Efficacy and Safety of a New Nutritional Supplement in Androgenetic Alopecia: A Pilot Study. A small open-label pilot tested a nutritional supplement with vitamin D, omega fatty acids, melatonin and botanical 5-alpha reductase inhibitors as adjunct therapy for pattern hair loss.