October 201728
A spermidine supplement was found to increase anagen follicles and keep pull tests negative. Electrodynamic microneedling added to minoxidil was reported to double hair-density gains versus minoxidil alone. A review identified home-use photobiomodulation devices as FDA-cleared with good safety but no head-to-head comparisons. Plasma growth factors with FUE was reported to reduce healing time, pain and itching and improve graft integrity. A meta-analysis found male pattern baldness associated with higher odds of aggressive prostate cancer and BPH. Focal atrichia was found far more often in female pattern hair loss than in other hair disorders, suggesting a diagnostic clue. A review found scalp hypothermia in chemotherapy cuts hair loss three- to fourfold, though optimal use lacks guidelines.
- A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study In a 100-person randomized placebo-controlled trial, a spermidine supplement increased anagen follicles and kept pull tests negative at six months.
- Randomized trial of electrodynamic microneedle combined with 5% minoxidil topical solution for the treatment of Chinese male Androgenetic alopecia In a 60-man randomized trial, adding electrodynamic microneedling to 5% minoxidil doubled hair-density gains versus minoxidil alone, with similar tolerability.
- Photobiomodulation therapy for androgenetic alopecia: A clinician’s guide to home-use devices cleared by the Federal Drug Administration A review identified 13 FDA-cleared home-use photobiomodulation devices for androgenetic alopecia with good safety but no head-to-head comparisons and lacking long-term data.
- Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle In mice, topical inhibition of the electron transport chain safely activated hair follicle stem cells and accelerated the hair cycle, even in aged mice.
- The effect of plasma rich in growth factors combined with follicular unit extraction surgery for the treatment of hair loss: A pilot study In a 30-patient pilot, adding plasma rich in growth factors to FUE reduced healing time, pain and itching and improved graft integrity.
- Hair Transplantation Controversies A review of hair transplant controversies covers donor harvesting methods and the roles of PRP and low-level light therapy, with no settled conclusions.
- Association between male pattern baldness and prostate disease: A meta-analysis A meta-analysis of 68,448 men found male pattern baldness associated with higher odds of aggressive prostate cancer (OR 1.59) and BPH (OR 1.26).
- Oral tofacitinib: a promising treatment in atopic dermatitis, alopecia areata and vitiligo oral tofacitinib is presented as a promising treatment for atopic dermatitis, alopecia areata and vitiligo.
- Focal atrichia: A diagnostic clue in female pattern hair loss Focal atrichia was found in 44% of women with female pattern hair loss versus 2% with other hair disorders, making it a diagnostic clue.
- New-Generation Therapies for the Treatment of Hair Loss in Men A review describes robotic transplantation, follicular unit extraction, and adjuvants like PRP, lasers and stem cells for male hair restoration.
- Scalp hypothermia as a preventative measure for chemotherapy‐induced alopecia: a review of controlled clinical trials A review of controlled trials finds scalp cooling cuts chemotherapy-induced hair loss roughly 3-4 fold, though optimal use lacks guidelines.
- Alopecia Areata. Current situation and perspectives a review of the current situation and perspectives in alopecia areata.
- Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway In mice, Gsdma3 acts via Wnt5a and non-canonical Wnt signaling to regulate hair follicle differentiation.
- Characterization of minoxidil/hydroxypropyl-β-cyclodextrin inclusion complex in aqueous alginate gel useful for alopecia management: Efficacy evaluation in male rat In rats, a cyclodextrin-alginate minoxidil gel grew hair as well as standard solution while being less toxic to skin cells.
- Frontal Fibrosing Alopecia: Update and Review of Challenges and Successes A review of frontal fibrosing alopecia found no randomized trials and no treatment proven to stop hairline recession.
- Preservation of stem cells in androgenetic alopecia paper concerns preservation of stem cells in androgenetic alopecia.
- Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells Mice lacking the ACER1 enzyme lose hair follicle stem cells and progressively lose hair, linking ceramide metabolism to follicle maintenance.
- Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life In human organ culture, intermediate facial follicles grew more hair with androgens while donor-matched terminal follicles stayed insensitive, modeling hormone-dependent hair responses.
- Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System that Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice In mice, safflower oil-body-delivered rhFGF-10 penetrated skin better and promoted wound healing and hair growth more than standard rhFGF-10.
- Titrated extract of<i>Centella asiatica</i>increases hair inductive property through inhibition of STAT signaling pathway in three-dimensional spheroid cultured human dermal papilla cells In cultured human dermal papilla spheroids, Centella asiatica extract boosted hair-inductive capacity by inhibiting STAT signaling.
- Skin transcriptome reveals the intrinsic molecular mechanisms underlying hair follicle cycling in Cashmere goats under natural and shortened photoperiod conditions In cashmere goats, short photoperiod triggers early anagen and CSDC2 emerges as a candidate hair-cycle regulator.
- Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury In irradiated mice, mTORC1 signaling was required for hair follicles to regenerate their growth cells and resume hair growth after radiation injury.
- Platelet-rich plasma stimulates angiogenesis in mice which may promote hair growth In mice, platelet-rich plasma injections lengthened hair and increased blood-vessel formation around follicles, suggesting angiogenesis promotes growth.
- Hair and nail diseases in the mature patient A review describes common hair and nail diseases in elderly patients, including androgenetic and senile alopecia and frontal fibrosing alopecia.
- Screening Guidelines for Thyroid Function in Children With Alopecia Areata In 298 children with alopecia areata, thyroid screening is recommended only with Down syndrome, atopy, family history, or goiter.
- Circulating and intraprostatic sex steroid hormonal profiles in relation to male pattern baldness and chest hair density among men diagnosed with localized prostate cancers In 248 prostate cancer patients, balding status was associated with higher circulating testosterone, DHT, estradiol and SHBG, but not intraprostatic hormones.
- Efficacy of Isotretinoin and Acitretin in Treatment of Frontal Fibrosing Alopecia: Retrospective Analysis of 54 Cases. In 54 women with frontal fibrosing alopecia, isotretinoin or acitretin stabilized hairline recession in ~75%, versus 43% on finasteride.
- The increasing incidence of frontal fibrosing alopecia. In search of triggering factors paper examines the rising incidence of frontal fibrosing alopecia in search of triggering factors.