June 201730
FUE hair transplantation was found a recognised alternative to strip harvesting, with less donor discomfort but a longer, more laborious procedure. Mechanically isolated follicle stem cell injections were reported to increase hair density 29% over baseline versus under 1% for placebo in AGA patients. A review of PRP for androgenetic alopecia found most studies showed increased terminal hair density or diameter, though optimal regimens remain undetermined. Topical 1% cetirizine was reported to increase total and terminal hair density and shaft diameter versus placebo. Gene expression analysis of minoxidil foam showed upregulated keratin genes and downregulated ILK, Akt and MAPK pathways in men with AGA. For alopecia areata, a review concluded JAK inhibitors and targeted drugs could transform treatment, while a subtype-based treatment algorithm was proposed, noting current therapies have minimal long-term efficacy.
- Follicular Unit Extraction for Hair Transplantation: An Update A review of FUE hair transplantation finds it a recognised alternative to strip harvesting with less donor discomfort and barely visible scarring, but a longer, more laborious procedure.
- Up-to-date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss A review finds adipose stem cell conditioned media promising for pattern hair loss, citing animal data and the authors' own clinical pilot studies.
- Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss In 11 AGA patients, mechanically isolated hair follicle stem cell injections increased hair density 29% over baseline at 23 weeks versus under 1% for placebo.
- The Changing Landscape of Alopecia Areata: The Translational Landscape A review describes how genetic and translational research is driving rapid development of targeted therapies for alopecia areata.
- The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm A review describes how JAK inhibitors and other mechanism-targeted drugs in trials could transform treatment of severe alopecia areata, which currently lacks approved therapies.
- Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature A review of 12 studies (295 patients) found most showed PRP increases terminal hair density or diameter in AGA, though optimal regimens remain undetermined.
- Management of alopecia areata: Updates and algorithmic approach A review proposes an alopecia areata treatment algorithm by subtype, severity and activity, noting current therapies have minimal long-term efficacy and new biologics are emerging.
- Methotrexate for the treatment of pediatric alopecia areata In a retrospective series of 14 children with alopecia areata, methotrexate produced good regrowth in 57%, with no discontinuations from side effects.
- A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia In a pilot study of 67 AGA patients, topical 1% cetirizine increased total and terminal hair density and shaft diameter versus placebo.
- Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice In mice, blocking CXCL4 with a monoclonal antibody triggered earlier anagen, delayed follicle regression, and promoted hair growth.
- Higher concentrations of dithranol appear to induce hair growth even in severe alopecia areata In 102 patients with steroid-resistant alopecia areata, dithranol up to 3% produced at least 50% regrowth in 37-62% depending on severity, including severe disease.
- An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia Gene expression analysis in men with AGA showed 5% minoxidil foam upregulates keratin genes and downregulates ILK, Akt, MAPK pathways in both scalp regions.
- Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis Blocking the CXXC5-Dishevelled interaction with a competing peptide activated Wnt signaling and accelerated hair regrowth and new follicle formation in mice.
- Three-microneedle device as an effective option for intralesional corticosteroid administration for the treatment of alopecia areata a three-microneedle device is presented as an option for intralesional corticosteroid delivery in alopecia areata.
- Hair growth promoting activity of discarded biocomposite keratin extract Topical keratin extract induced the anagen growth phase and increased follicle number in mice, with over 90% cell viability in vitro.
- Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study A computational model predicts open hair follicles raise systemic bioavailability of topical caffeine by about 20% versus blocked follicles.
- Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth In mice, dermal Blimp1 acts downstream of TGF-beta and Wnt/beta-catenin to drive dermal papilla signaling that initiates hair follicle growth.
- Transcriptome Analysis of Skin from SMP30/GNL Knockout Mice Reveals the Effect of Ascorbic Acid Deficiency on Skin and Hair In vitamin C-deficient mice, vitamin C supplementation promoted hair growth, with gene changes in keratin and Sonic hedgehog pathways.
- From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots A review explains how hedgehog pathway inhibitors used for basal cell carcinoma cause alopecia by disrupting normal hair follicle cycling.
- Topical Janus kinase inhibitors for the treatment of pediatric alopecia areata reports on topical JAK inhibitors for treating pediatric alopecia areata.
- Systematic review and quality analysis of studies on the efficacy of topical diphenylcyclopropenone treatment for alopecia areata systematic review and quality analysis of topical diphenylcyclopropenone for alopecia areata.
- Aging in hair follicle stem cells and niche microenvironment A review summarizes how aging of hair follicle stem cells and their niche drives hair loss, suggesting avenues for new therapies.
- Editorial - Mesenchymal Stem Cells in Androgenic Alopecia: Hair Loss Regeneration. editorial on mesenchymal stem cells for hair regeneration in androgenic alopecia.
- Platelet-Rich Plasma Growth Factor Concentrated Spray (Keratogrow®) as a Potential Treatment for Androgenic Alopecia. Autologous PRP concentrated spray applied twice daily for three months increased hair number and density in treated AGA patients.
- Efficacy of Activated 3X Platelet-Rich Plasma in the Treatment of Androgenic Alopecia. In five AGA patients, three months of PRP injections improved hair counts, thickness, and root strength with no major adverse effects.
- Letter to the Editor: “Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss” A letter argues a post-finasteride study cannot rule out finasteride's role in persistent sexual symptoms, citing methodological limitations.
- Response to Letter: “Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss” Reply letter: persistent sexual symptoms after finasteride showed no evidence of ongoing androgen deficiency or 5α-reductase inhibition in blood, skin, or genes.
- Dyslipidemia in patients with androgenetic alopecia. Statins, finasteride or both? A commentary notes meta-analysis evidence that androgenetic alopecia patients have an atherogenic lipid profile, possibly linking AGA to cardiovascular risk.
- T-Regulating Hair Follicle Stem Cells A commentary highlights findings that skin regulatory T cells localize to the hair follicle stem cell niche to control hair regeneration.
- Aryl hydrocarbon receptor overexpression in miniaturized follicles in female pattern hair loss Aryl hydrocarbon receptors are overexpressed in miniaturized follicles of women with pattern hair loss, hinting at a pollution link.